John C Lord

US Patent:

57337390, Mar 31, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/523972

Inventors:

David S. Zakim - Armonk NY
John B. Lord - New York NY

Assignee:

InPhoCyte, Inc. - White Plains NY

International Classification:

C12Q 102
C12Q 104
G01N 3353
G01J 328

US Classification:

435 29

Abstract:

A machine-based method for collecting and interpreting quantitative data on cells and tissues so that a diagnosis will obtain as to the existence or non-existence of disease in an human. Vibrational spectroscopy is used and the spectra generated by such spectroscopy are compared with stored spectra to provide whether cells or tissues are diseased, and if diseased to what degree. It, therefore, is possible to provide a basis for immediate diagnostic decisions for patients and physicians, leading in turn to immediate implementation of next-step procedures and treatment all in one visit to the doctor's office. This means that patients and the examining clinician can know almost instantly whether or not the cells or tissue examined are normal or diseased, and the level of disease present if found. The advantages of bringing the diagnostic pathology service directly into the doctor's office include immediate relief to the patient's concern about health as well as immediate clarification of what needs to be done next in order to treat the disease that is present, and include any other actions that are necessary. The need for biopsies to obtain desired information on the existence or non-existence of disease is obviated.

US Patent:

20180312475, Nov 1, 2018

Filed:

Jan 28, 2016

Appl. No.:

15/545331

Inventors:

- Ingelheim am Rhein, DE
Jörg M. BENTZIEN - White Plains NY, US
Jennifer BURKE - Newtown CT, US
Derek COGAN - Ridgefield CT, US
Xin GUO - Danbury CT, US
Keith R. HORNBERGER - Southbury CT, US
John LORD - Poughkeepsie NY, US
Kenneth M. MEYERS - Seymour CT, US
Zhaoming XIONG - Ridgefield CT, US
Maolin YU - Brookfield CT, US
Zhonghua ZHANG - Ridgefield CT, US

International Classification:

C07D 261/20
C07D 413/10
C07D 413/04
C07D 413/06
C07D 413/12
C07D 498/04
A61P 13/12

Abstract:

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.