John C Maclean

US Patent:

20220304628, Sep 29, 2022

Filed:

Jun 7, 2022

Appl. No.:

17/834281

Inventors:

- London, GB
Paul J. Gaudet - Dracut MA, US
John Edgar MacLean - Newton MA, US

International Classification:

A61B 5/00
A61B 5/11
A61B 5/259
G16H 20/40
G16H 50/20

Abstract:

A monitor comprises circuitry to receive a signal and process the signal to monitor at least one characteristic of a subject, and a flexible polymer casing forming a waterproof enclosure for the circuitry. The flexible polymer casing is infused with a conductive material at at least one location to form at least one infused electrode that extends from an exterior of the flexible polymer casing to an interior of the flexible polymer casing, and the at least one infused electrode is coupled to the circuitry so as to allow the signal to pass from outside the flexible polymer casing to the circuitry. A polymer in a portion of the flexible polymer casing that is infused with the conductive material at the at least one location is cross-linked with a polymer in a portion of the flexible polymer casing that is not infused with the conductive material.

US Patent:

20200375548, Dec 3, 2020

Filed:

Jun 26, 2020

Appl. No.:

16/913331

Inventors:

- London, GB
Paul J. Gaudet - Dracut MA, US
John Edgar MacLean - Newton MA, US

International Classification:

A61B 5/00
A61B 5/0408
A61B 5/11
G16H 20/40
G16H 50/20

Abstract:

A monitor comprises circuitry to receive a signal and process the signal to monitor at least one characteristic of a subject, and a flexible polymer casing forming a waterproof enclosure for the circuitry. The flexible polymer casing is infused with a conductive material at at least one location to form at least one infused electrode that extends from an exterior of the flexible polymer casing to an interior of the flexible polymer casing, and the at least one infused electrode is coupled to the circuitry so as to allow the signal to pass from outside the flexible polymer casing to the circuitry. A polymer in a portion of the flexible polymer casing that is infused with the conductive material at the at least one location is cross-linked with a polymer in a portion of the flexible polymer casing that is not infused with the conductive material.

US Patent:

20180022701, Jan 25, 2018

Filed:

Jul 12, 2017

Appl. No.:

15/647437

Inventors:

- RAHWAY NJ, US
Corey E. Bienstock - Natick MA, US
John K. Maclean - Brookline MA, US
Hongjun Zhang - Newton MA, US
Richard T. Beresis - Shanghai, CN
Dongshan Zhang - Shanghai, CN
Neville J. Anthony - Northborough MA, US
Blair T. Lapointe - Brookline MA, US
Yuan Tian - Boston MA, US

International Classification:

C07D 209/26
C07D 471/04
C07D 401/06
C07D 403/06
C07D 405/06
C07D 413/06
C07D 401/04
C07D 403/04
C07D 409/04
C07D 413/04
C07D 417/04
A61K 31/404
A61K 31/5377
A61K 31/4439
A61K 31/437
A61K 31/416
C07D 405/12
C07D 231/56

Abstract:

The present invention relates to compounds according to Formula I (Formula I), and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

US Patent:

20170265769, Sep 21, 2017

Filed:

Jun 1, 2017

Appl. No.:

15/610974

Inventors:

- London, GB
Paul J. Gaudet - Dracut MA, US
John Edgar MacLean - Newton MA, US

International Classification:

A61B 5/0408
A61B 5/00
A61B 5/11
G06F 19/00
G01C 22/00

Abstract:

A health-monitor patch comprising at least one physiological sensor and digital processor is configured to be adhered to the skin of a subject. A health-monitor patch may further include an accelerometer and may detect cardiac waveforms, activity performed by the subject, and a body orientation of the subject. A health-monitor patch may be disposable, in some embodiments, and used for outpatient monitoring. Aspects of noise cancellation and reel-to-reel manufacturing are also described.

US Patent:

20170000371, Jan 5, 2017

Filed:

Sep 15, 2016

Appl. No.:

15/267042

Inventors:

- London, GB
Paul J. Gaudet - Dracut MA, US
John Edgar MacLean - Newton MA, US

Assignee:

LumiraDx UK Ltd - London

International Classification:

A61B 5/0408
A61B 5/00
A61B 5/11

Abstract:

A health-monitor patch comprising at least one physiological sensor and digital processor is configured to be adhered to the skin of a subject. A health-monitor patch may further include an accelerometer and may detect cardiac waveforms, activity performed by the subject, and a body orientation of the subject. A health-monitor patch may be disposable, in some embodiments, and used for outpatient monitoring. Aspects of noise cancellation and reel-to-reel manufacturing are also described.

US Patent:

20170000372, Jan 5, 2017

Filed:

Sep 15, 2016

Appl. No.:

15/266767

Inventors:

- London, GB
Paul J. Gaudet - Dracut MA, US
John Edgar MacLean - Newton MA, US

Assignee:

LumiraDx UK Ltd - London

International Classification:

A61B 5/0408
A61B 5/11
A61B 5/00

Abstract:

A health-monitor patch comprising at least one physiological sensor and digital processor is configured to be adhered to the skin of a subject. A health-monitor patch may further include an accelerometer and may detect cardiac waveforms, activity performed by the subject, and a body orientation of the subject. A health-monitor patch may be disposable, in some embodiments, and used for outpatient monitoring. Aspects of noise cancellation and reel-to-reel manufacturing are also described.

US Patent:

20160311787, Oct 27, 2016

Filed:

Dec 19, 2014

Appl. No.:

15/103409

Inventors:

- Rahway NJ, US
- Ann Arbor MI, US
John MacLean - Brookline MA, US
Brian M. Andresen - Boston MA, US
Kenneth J. Barr - Boston MA, US
Corey Bienstock - Natick MA, US
Matthew Daniels - Somerville MA, US
Kun Liu - Boston MA, US
Yuan Liu - Billerica MA, US
Catherine White - Boston MA, US
Nunzio Sciammetta - Boston MA, US
Vladimir Simov - Boston MA, US

International Classification:

C07D 265/36
C07D 413/12
C07D 417/12
C07D 471/04
C07D 513/04
A61K 31/538
C07D 487/04

Abstract:

The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R, R, R, R, R, R, R, R, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

US Patent:

20160304505, Oct 20, 2016

Filed:

Dec 19, 2014

Appl. No.:

15/103407

Inventors:

- Rahway NJ, US
- Ann Arbor MI, US
John MacLean - Brookline MA, US
Brian M. Andresen - Boston MA, US
Kenneth J. Barr - Boston MA, US
Corey Bienstock - Natick MA, US
Neville J. Anthony - Northborough MA, US
Matthew Daniels - Somerville MA, US
Yuan Liu - Billerica MA, US
Catherine White - Boston MA, US
Blair T. Lapointe - Boston MA, US
Nunzio Sciammetta - Boston MA, US
Vladimir Simov - Boston MA, US
Wesley B. Trotter - Boston MA, US
Kun Liu - Boston MA, US

International Classification:

C07D 413/12
A61K 31/538
C07D 265/36
C07D 413/14
C07D 498/04
C07D 513/04
C07D 487/04
C07D 417/12
A61K 45/06
C07D 471/04

Abstract:

The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, R, R, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.