John B Mangrum

age ~48

from Cheverly, MD

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Connected to:

John Mangrum Phones & Addresses

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Specialties:

Psychiatry

Education:

Johns Hopkins University (1967)

Cinnamic Acid-Based Oligomers And Uses Thereof
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US Patent:

8613909, Dec 24, 2013
Filed:

Jun 25, 2013
Appl. No.:

13/926008
Inventors:

Brian L. Henry - Pittsburgh PA, US
Aiye Liang - North Charleston SC, US
Jay Thakkar - Denver CO, US
John B. Mangrum - Richmond VA, US
Ivo Torres Filho - San Antonio TX, US
Bruce D. Spiess - Manakin-Sabot VA, US
Masahiro Sakagami - Richmond VA, US
Bhawana Saluja - North Bethesda MD, US
Assignee:

Virginia Commonwealth University - Richmond VA
International Classification:

A61K 9/12
A61K 31/185
A61K 31/192
A61K 31/343
A61K 31/255
C07C 305/24
C07D 307/80
C07D 307/84
C07D 407/14
A61P 7/02
A61P 29/00
A61P 11/00
US Classification:

424 45, 514469, 514518, 549468, 562 36
Abstract:

Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e. g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e. g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.

Cinnamic Acid-Based Oligomers And Uses Thereof
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US Patent:

20120027691, Feb 2, 2012
Filed:

Aug 4, 2009
Appl. No.:

13/057374
Inventors:

Umesh R. Desai - Glen Allen VA, US
Brian L. Henry - Pittsburgh PA, US
Aiye Liang - North Charleston SC, US
Jay Thakkar - Denver CO, US
John B. Mangrum - Richmond VA, US
Ivo Torres Filho - Glen Allen VA, US
Bruce D. Spiess - Manakin-Sabot VA, US
Masahiro Sakagami - Richmond VA, US
Bhawana Saluja - N. Bethesda MD, US
International Classification:

A61K 31/255
C07D 407/14
A61K 9/12
A61P 7/02
A61P 29/00
A61P 11/00
C07C 305/24
A61K 31/343
US Classification:

424 45, 562 36, 514518, 549468, 514469
Abstract:

Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.

Cinnamic Acid-Based Oligomers And Uses Thereof
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US Patent:

20140080904, Mar 20, 2014
Filed:

Nov 22, 2013
Appl. No.:

14/087706
Inventors:

Brian L. Henry - Pittsburgh PA, US
Aiye Liang - North Charleston SC, US
Jay Thakkar - Denver CO, US
John B. Mangrum - Richmond VA, US
Ivo Torres Filho - San Antonio TX, US
Bruce D. Spiess - Manakin-Sabot VA, US
Masahiro Sakagami - Richmond VA, US
Bhawana Saluja - North Bethesda MD, US
Assignee:

Virginia Commonwealth University - Richmond VA
International Classification:

C07D 307/84
US Classification:

514469, 549468
Abstract:

Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.