John T Mauro

US Patent:

8647577, Feb 11, 2014

Filed:

Oct 10, 2012

Appl. No.:

13/648663

Inventors:

John Matthew Mauro - Burlingame CA, US
Shifeng Li - Fremont CA, US
James Bustillo - Castro Valley CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

G01N 27/00
G01N 27/30
B05D 5/12
B28B 19/00
B29B 15/10
C23C 18/00
C23C 20/00
C23C 24/00
C23C 26/00
C23C 28/00
C23C 30/00
H01C 17/06
H05K 3/00
H01L 21/00
G01N 30/96

US Classification:

422 8201, 422 69, 422 8203, 427 971, 427 977, 427 978, 436 94, 438 49

Abstract:

The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.

US Patent:

20110220844, Sep 15, 2011

Filed:

Oct 2, 2009

Appl. No.:

13/119557

Inventors:

Eric Tulsky - Berkeley CA, US
Eric Welch - Eugene OR, US
Bruce Branchaud - Eugene OR, US
John Mauro - Eugene OR, US
Imad Naasani - Manchester, GB

International Classification:

C09K 11/02
C09K 11/54
C09K 11/62
C09K 11/88
C09K 11/56
B82Y 30/00
B82Y 40/00

US Classification:

25230136, 977773, 977896

Abstract:

A nanoparticle having one or more phosphonates or phosphinate ligands on their surface can be converted into nanoparticles with sulfonate ligands on their surface, by contacting the phosphonate-containing nanoparticles with a silylsulfonate reagent. Such nanoparticles are activated toward reactions with nucleophilic groups; thus the method provides activated nanoparticles, and methods of making and using them to produce modified nanoparticles.

US Patent:

20110306079, Dec 15, 2011

Filed:

Aug 6, 2009

Appl. No.:

13/057504

Inventors:

Eric Tulsky - Berkeley CA, US
Kari Haley - Eugene OR, US
Imad Naasani - Manchester, GB
John Mauro - Eugene OR, US
Joseph A. Treadway - Eugene OR, US

International Classification:

C12Q 1/02
G01N 21/75
B82B 1/00
B82B 3/00
B82Y 15/00

US Classification:

435 29, 436501, 977773, 977902, 977810, 977834

Abstract:

Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.

US Patent:

20140113303, Apr 24, 2014

Filed:

Dec 23, 2013

Appl. No.:

14/139647

Inventors:

- Carlsbad CA, US
John M. MAURO - Burlingame CA, US
Shifeng LI - Fremont CA, US
James BUSTILLO - Castro Valley CA, US

Assignee:

LIFE TECHNOLOGIES CORPORATION - Carlsbad CA

International Classification:

G01N 27/414
C12Q 1/68
G01N 27/26

US Classification:

435 612, 436 94, 422 8201, 422 69, 4352872

Abstract:

The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.