John F Monahan

US Patent:

6504019, Jan 7, 2003

Filed:

Mar 21, 2001

Appl. No.:

09/813644

Inventors:

Guohan Yang - Mansfield MA
Donna M. Ford - Plainville MA
Say-Jong Law - Westwood MA
John E. Monahan - Walpole MA
Todd B. Sells - Bellingham MA

Assignee:

Bayer Corporation - Medfield MA

International Classification:

C07H 2104

US Classification:

536 221, 536 231, 435 6, 544 83, 935 22, 935 28, 935 76

Abstract:

Highly hydrophilic non-nucleosidic tags with multiple labels are provided for use in nucleic acid probes. The tags are branched structures having a phosphodiester backbone, which have the advantages of a small dimensional size and high hydrophilicity. After the tag is labeled, its high negative charge and minimal size help to keep the carriers away from DNA or RNA molecules, due to repulsion between negative charges. Non-specific intercalation and steric hindrance are therefore minimized, and the hydrophobicity, if any of reporter molecules is reduced. The probes are used in place of conventionally labeled oligonucleotides for a variety of hybridization reactions.

US Patent:

7125663, Oct 24, 2006

Filed:

Jun 12, 2002

Appl. No.:

10/171311

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Cambridge MA, US
Xumei Zhao - Burlington MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersh - Arlington MA, US

Assignee:

Millenium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12Q 1/68

US Classification:

435 6, 435 723, 530350, 5303877, 5303913, 536 235, 536 2431, 436 65

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7601505, Oct 13, 2009

Filed:

May 26, 2004

Appl. No.:

10/855588

Inventors:

John E. Monahan - Walpole MA, US
Sebastian Hoersch - Arlington MA, US
Dustin L. Anderson - Brighton MA, US
Wilson O. Endege - Norwood MA, US
Donna Ford - Plainville MA, US
Karen Glatt - Natick MA, US
Bella O. Gorbatcheva - Boston MA, US
Shubhangi Kamatkar - Newton MA, US
Yong Yao Xu - Belmont MA, US
Manjula Gannavarapu - Acton MA, US
Xumei Zhao - Wayland MA, US
Robert Schlegel - Auburndale MA, US
Maureen Mertens - Stow MA, US
Gabriel N. Hortobagyi - Bellaire TX, US
Lajos Pusztai - Pearland TX, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
Board of Regents, The University of Texas Systems - Austin TX

International Classification:

G01N 33/53
C12Q 1/70

US Classification:

435 71, 435 5

Abstract:

The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.

US Patent:

7705120, Apr 27, 2010

Filed:

Jun 21, 2002

Appl. No.:

10/177293

Inventors:

James Lillie - Westin MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US
Shubhangi Kamatkar - Newton MA, US
Maureen Mertens, Hattersley - Stow MA, US
John E. Monahan - Walpole MA, US
Vickesh Myer - Harvard MA, US
Youzhen Wang - Newton MA, US
Yongyao Xu - Belmont MA, US
Xumei Zhao - Wayland MA, US
Rachel E. Meyers - Newton MA, US
Gabriel N. Hortobagyi - Houston TX, US
Lajos Pusztai - Bellaire TX, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
Board of Regents, University of Texas System - Austin TX

International Classification:

C07K 1/00
C07K 14/00
C07K 17/00
C07H 1/00
C07H 5/00
C07H 21/00
C08B 37/00

US Classification:

530350, 536 111, 536 187, 536 231, 536 234, 536 235

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.

US Patent:

7799518, Sep 21, 2010

Filed:

Oct 7, 2004

Appl. No.:

10/961139

Inventors:

Wilson O. Endege - Norwood MA, US
Donna Ford - Plainville MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US
Shubhangi Kamatkar - Newton MA, US
John E. Monahan - Walpole MA, US
Robert Schlegel - Auburndale MA, US
Yong Yao Xu - Belmont MA, US
Xumei Zhao - Wayland MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA
Board of Regents, University of Texas System - Austin TX

International Classification:

C12Q 1/00
C12Q 1/68
G01N 33/53
G01N 33/574

US Classification:

435 4, 435 6, 435 71, 435 723

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers are provided.

US Patent:

7846737, Dec 7, 2010

Filed:

Aug 25, 2006

Appl. No.:

11/510530

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Acton MA, US
Xumei Zhao - Wayland MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/48
G01N 33/574

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 5303877, 536 235, 536 243

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

8062892, Nov 22, 2011

Filed:

Jun 14, 2010

Appl. No.:

12/814849

Inventors:

Robert Schlegel - Auburndale MA, US
Yan Chen - Acton MA, US
Xumei Zhao - Wayland MA, US
John E. Monahan - Walpole MA, US
Shubhangi Kamatkar - Newton MA, US
Manjula Gannavarapu - Acton MA, US
Karen Glatt - Natick MA, US
Sebastian Hoersch - Arlington MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/48
G01N 33/574

US Classification:

436 64, 435 6, 435 71, 435 723, 530350, 5303877, 536 235, 536 243

Abstract:

The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.

US Patent:

7361511, Apr 22, 2008

Filed:

Aug 20, 2003

Appl. No.:

10/645756

Inventors:

John E. Monahan - Walpole MA, US
Xumei Zhao - Wayland MA, US
Yan Chen - Cambridge MA, US

Assignee:

Millenium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33/50

US Classification:

436 64, 435 6, 435 723, 530350, 5303877, 536 231, 536 235, 536 243

Abstract:

The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.