John C Munger

US Patent:

6518438, Feb 11, 2003

Filed:

Sep 27, 2001

Appl. No.:

09/967368

Inventors:

Kenneth M. Kent - Sunnyvale CA
Choung U. Kim - San Carlos CA
Lawrence R. McGee - Pacifica CA
John D. Munger - Alviso CA
Ernest J. Prisbe - Los Altos CA
Michael J. Postich - Walnut Creek CA
John C. Rohloff - Mountain View CA
Daphne E. Kelly - San Francisco CA
Matthew A. Williams - Foster City CA
Lijun Zhang - Foster City CA

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D20326

US Classification:

548961, 549437, 549513, 560126

Abstract:

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

US Patent:

20020045599, Apr 18, 2002

Filed:

Sep 10, 2001

Appl. No.:

09/950031

Inventors:

Murty Arimilli - Fremont CA, US
Daphne Kelly - San Francisco CA, US
Thomas Lee - Redwood City CA, US
Lawrence Manes - Moss Beach CA, US
John Munger - Alviso CA, US
Ernest Prisbe - Los Altos CA, US
Lisa Schultze - San Carlos CA, US

Assignee:

Gilead Sciences, Inc.

International Classification:

A61K031/675
C07F009/6512

US Classification:

514/081000, 544/244000

Abstract:

The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.

US Patent:

20020058823, May 16, 2002

Filed:

Dec 19, 2000

Appl. No.:

09/740504

Inventors:

Kenneth Kent - Sunnyvale CA, US
Choung Kim - San Carlos CA, US
Lawrence McGee - Pacifica CA, US
John Munger - Alviso CA, US
Ernest Prisbe - Los Altos CA, US
Michael Postich - Walnut Creek CA, US
John Rohloff - Mountain View CA, US
Daphne Kelly - San Francisco CA, US
Matthew Williams - Foster City CA, US
Lijun Zhang - Foster City CA, US

Assignee:

GILEAD SCIENCES, INC.

International Classification:

C07D317/44
C 07D 3 3/00
C 07D 2 3/26
C 07C 3 3/00

US Classification:

549/436000, 549/546000, 548/961000, 558/052000

Abstract:

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

US Patent:

58592849, Jan 12, 1999

Filed:

Aug 23, 1996

Appl. No.:

8/701942

Inventors:

Kenneth M. Kent - Sunnyvale CA
Choung U. Kim - San Carlos CA
Lawrence R. McGee - Pacifica CA
John D. Munger - Alviso CA
Ernest J. Prisbe - Los Altos CA
Michael J. Postich - San Mateo CA
John C. Rohloff - Mountain View CA
Daphne E. St. John - San Francisco CA
Matthew A. Williams - Foster City CA
Lijun Zhang - Foster City CA

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07C 69757
C07D20326
C07D31746
C07D30700

US Classification:

560125

Abstract:

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

US Patent:

62043986, Mar 20, 2001

Filed:

Apr 28, 1999

Appl. No.:

9/242119

Inventors:

Kenneth M. Kent - Sunnyvale CA
Choung U. Kim - San Carlos CA
Lawrence R. McGee - Pacifica CA
John D. Munger - Alviso CA
Ernest J. Prisbe - Los Altos CA
Michael J. Postich - Walnut Creek CA
John C. Rohloff - Mountain View CA
Daphne E. Kelly - San Francisco CA
Matthew A. Williams - Foster City CA
Lijun Zhang - Foster City CA

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07D31744
C07D30300
C07D20326
C07C 6974
C07C20500

US Classification:

549436

Abstract:

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided. ##STR1##.

US Patent:

57926085, Aug 11, 1998

Filed:

Apr 6, 1995

Appl. No.:

8/417632

Inventors:

Sundaramoorthi Swaminathan - Burlingame CA
Mark Matteucci - Burlingame CA
Robert J. Jones - Millbrae CA
Jeff Pudlo - Burlingame CA
John Munger - San Francisco CA

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Oligomers are disclosed which have modified internucleotide linkages and can form triplex and duplex structures by binding to complementary nucleic acid sequences. The oligomers of the invention may be incorporated into carriers and may be constructed to have any desired sequence. Compositions of the invention can be used for diagnostic purposes in order to detect viruses or disease conditions.

US Patent:

55960863, Jan 21, 1997

Filed:

Sep 20, 1991

Appl. No.:

7/763130

Inventors:

Mark Matteucci - Burlingame CA
Robert J. Jones - Daly City CA
John Munger - San Francisco CA

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07H 2100
C07H 2102
C07H 2104
A61K 3170

US Classification:

536 221

Abstract:

Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. The oligomers of the invention may be used as diagnostic reagents to detect the presence or absence of the target DNA or RNA sequences to which they bind.

US Patent:

59359463, Aug 10, 1999

Filed:

Jul 25, 1997

Appl. No.:

8/900752

Inventors:

John D. Munger - Alviso CA
John C. Rohloff - Mountain View CA
Lisa M. Schultze - San Carlos CA

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31675

US Classification:

514 81

Abstract:

The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxyphosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.