John R O'Connell

US Patent:

58916210, Apr 6, 1999

Filed:

Sep 24, 1997

Appl. No.:

8/936646

Inventors:

Renee M. Chabin - Neptune NJ
David W. Kuo - Princeton NJ
John F. O'Connell - Cranbury NJ
David L. Pompliano - Lawrenceville NJ
Kenny K. Wong - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12Q 100
C12Q 137
C12Q 118
C12Q 148

US Classification:

435 4

Abstract:

An in vitro screening assay which identifies enzyme inhibitors and allows for the simultaneous assay of many enzymes. Enzyme, substrate, co-factor, etc. concentrations are optimized so that inhibitors of any one of the enzymes in the pathway are equally likely to be detected. Necessarily, the flux of substrate through each enzyme should be nearly the same during the assay, i. e. , each of the enzyme catalyzed steps must be equally rate-limiting. Preferably, optimal assay conditions are predicted by computer modeling. Further, the pathway conditions are optimized through variation of enzyme, starting substrate, co-substrate and co-factor concentrations. A positive response is initially detected as a change in the amount of the product generated at the end of the enzyme cascade as compared to a standard. A sample producing a positive result can be deconvoluted.

US Patent:

20140172834, Jun 19, 2014

Filed:

Dec 19, 2013

Appl. No.:

14/134125

Inventors:

- Princeton Junction NJ, US
Thomas Kaminski - Lawrenceville NJ, US
John O'Connell - Princeton Junction NJ, US

Assignee:

R-Squared Technology Holdings, LLC - Princeton Junction NJ

International Classification:

G06F 17/30

US Classification:

707722

Abstract:

A method and system for providing access to aggregated data sets. The method includes organizing a plurality of data sets into an aggregated data set, providing access to at least a portion of the aggregated data set based upon a subscription level associated with a user, receiving a search query from the user to search the aggregated data, determining which portions of the aggregated data set the user can access based upon the subscription level of the user, filtering a set of search results based upon the determination of which portions of the aggregated data set the user can access, and returning the filtered search results to the user. The system includes various components for performing the method.

US Patent:

20140172835, Jun 19, 2014

Filed:

Dec 19, 2013

Appl. No.:

14/134135

Inventors:

- Princeton Junction NJ, US
Thomas Kaminski - Lawrenceville NJ, US
John O'Connell - Princeton Junction NJ, US

Assignee:

R-Squared Technology Holdings, LLC - Princeton Junction NJ

International Classification:

G06F 17/30

US Classification:

707722, 707755

Abstract:

A method and system for improving aggregated data sets through crowd sourcing. The method includes organizing a plurality of data sets into an aggregated data set, providing search access to at least a portion of the aggregated data set based upon a subscription level associated with a user, and returning results to the user. Organizing the plurality of data sets into an aggregated data set includes receiving data from a plurality of sources, parsing the data, translating the parsed data into its native format and content, tagging the parsed data with attributes detailing how the data is entered, wherein the attributes comprise geographic location information, and mapping the translated data into a plurality of database tables within the aggregated data set. The system includes various components for performing the method.