John Rv Perez

US Patent:

20210101943, Apr 8, 2021

Filed:

Dec 18, 2020

Appl. No.:

17/126712

Inventors:

- New York NY, US
Rasappa Gounder Arumugham - Lansdale PA, US
John Erwin Farley - Chapel Hill NC, US
Leah Diane Fletcher - Geneseo NY, US
Shannon Lea Harris - Nanuet NY, US
Kathrin Ute Jansen - New York NY, US
Thomas Richard Jones - New City NY, US
Lakshmi Khandke - Nanuet NY, US
Bounthon Loun - North Reading MA, US
John Lance Perez - Doylestown PA, US
Gary Warren Zlotnick - San Antonio TX, US

International Classification:

C07K 14/22
A61K 39/13
A61K 39/295
A61K 39/00
A61K 39/095
A61K 39/12
A61K 39/39
C12N 7/00

Abstract:

In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.

US Patent:

20180022783, Jan 25, 2018

Filed:

Oct 10, 2017

Appl. No.:

15/728610

Inventors:

- New York NY, US
Rasappa Gounder Arumugham - Lansdale PA, US
John Erwin Farley - Chapel Hill NC, US
Leah Diane Fletcher - Geneseo NY, US
Shannon Lea Harris - Nanuet NY, US
Kathrin Ute Jansen - New York NY, US
Thomas Richard Jones - New City NY, US
Lakshmi Khandke - Nanuet NY, US
Bounthon Loun - North Reading MA, US
John Lance Perez - Doylestown PA, US
Gary Warren Zlotnick - San Antonio TX, US

International Classification:

C07K 14/22
A61K 39/39
A61K 39/295
A61K 39/00
A61K 39/12
A61K 39/095
C12N 7/00
A61K 39/13

Abstract:

In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.

US Patent:

20150071959, Mar 12, 2015

Filed:

Aug 27, 2014

Appl. No.:

14/470922

Inventors:

- New York NY, US
Rasappa Gounder Arumugham - Lansdale PA, US
John Erwin Farley - Chapel Hill NC, US
Leah Diane Fletcher - Geneseo NY, US
Shannon Harris - Nanuet NY, US
Kathrin Ute Jansen - New York NY, US
Thomas Richard Jones - New City NY, US
Lakshmi Khandke - Nanuet NY, US
Bounthon Loun - Athens GA, US
John Lance Perez - Doylestown PA, US
Gary Warren Zlotnick - New Windsor NY, US

International Classification:

C07K 14/22
C12N 7/00
A61K 39/12
A61K 39/00
A61K 39/095
A61K 39/39

US Classification:

4241901

Abstract:

In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.