John W Pyhtila

US Patent:

7903254, Mar 8, 2011

Filed:

Aug 10, 2009

Appl. No.:

12/538309

Inventors:

Adam Wax - Chapel Hill NC, US
John W. Pyhtila - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

G01B 9/02
G01J 3/45
G01N 21/00

US Classification:

356456

Abstract:

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

US Patent:

8537366, Sep 17, 2013

Filed:

Mar 8, 2011

Appl. No.:

13/042672

Inventors:

Adam Wax - Chapel Hill NC, US
John W. Pyhtila - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

G01B 9/02
G01J 3/45

US Classification:

356456

Abstract:

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

US Patent:

20070133002, Jun 14, 2007

Filed:

Oct 11, 2006

Appl. No.:

11/548468

Inventors:

Adam Wax - Chapel Hill NC, US
John Pyhtila - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

G01B 9/02
G01B 11/02
G01J 3/45

US Classification:

356456000, 356479000, 356512000

Abstract:

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

US Patent:

20120281224, Nov 8, 2012

Filed:

Jul 17, 2012

Appl. No.:

13/551348

Inventors:

Adam Wax - Chapel Hill NC, US
John W. Pyhtila - Durham NC, US

Assignee:

DUKE UNIVERSITY - Durham NC

International Classification:

G01J 3/45
G01B 11/22
G01B 9/02

US Classification:

356456, 356450, 356498

Abstract:

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

US Patent:

20130265582, Oct 10, 2013

Filed:

Apr 23, 2013

Appl. No.:

13/868215

Inventors:

John W. Pyhtila - Durham NC, US

Assignee:

Duke University - Durham NC

International Classification:

G01J 3/45

US Classification:

356456

Abstract:

Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

US Patent:

20180008147, Jan 11, 2018

Filed:

Jun 27, 2017

Appl. No.:

15/634456

Inventors:

- Durham NC, US
John W. Pyhtila - Durham NC, US

International Classification:

A61B 5/00
G01J 3/45
G01N 21/47
G01N 21/31
G01B 9/02
A61B 1/00

Abstract:

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.

US Patent:

20150045677, Feb 12, 2015

Filed:

Sep 23, 2014

Appl. No.:

14/494080

Inventors:

- Durham NC, US
John W. Pyhtila - Durham NC, US

International Classification:

A61B 5/00
A61B 1/00
G01B 9/02

US Classification:

600477

Abstract:

A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.