John Joseph Regan

US Patent:

6372773, Apr 16, 2002

Filed:

Aug 2, 2001

Appl. No.:

09/920899

Inventors:

John R. Regan - Larchmont NY

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 31415

US Classification:

514404, 5483684

Abstract:

Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar ,Ar ,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

US Patent:

6800645, Oct 5, 2004

Filed:

Jul 7, 2000

Appl. No.:

09/612530

Inventors:

Paul Joseph Cox - Dagenham, GB
Shelley Bower - Dagenham, GB
David John Aldous - Dagenham, GB
Peter Charles Astles - Dagenham, GB
Daniel Gerard McGarry - King of Prussia PA
Christopher Hulme - Phoenixville PA
John Robinson Regan - Larchmont NY
Fu-Chih Huang - North Wales PA
Stevan Wakefield Djuric - Libertyville IL
Kevin Joseph Moriarty - Norristown PA
Rose Mappilakunnel Mathew - Phoenixville PA
Gregory Bernard Poli - Perkasie PA

Assignee:

Aventis Pharma Limited - Kent

International Classification:

A61K 3147

US Classification:

514314, 514308, 514309, 514312, 514313, 546169, 546140, 546141, 546146, 546153, 546156, 546158, 546159, 546165, 546166

Abstract:

This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; R represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms, or when Z represents a direct bond R may also represent a lower alkenyl or lower alkynyl group, or a formyl group; R represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, âSO NR R , âNR SO R , âNR R , âC( O)R , âC( O)C( O)R , âC( O)NR R , âC( O)OR , âO(C O)NR R , or âNR C( O)R ; R represents âC( Z)âN(R )R , âC( Z)âCHR R , âC( Z)âR , âCR C(R )(CH ) âR , âC(R ) C(R )R , âC(R )(R )C(R )(R )R , âC(R )(R )CH(R )(CH ) âR , âR , âV( Z)âR , âC(R ) NâOC( O)R , âC( O)âN(R )OR , âCâCâR , âCH âC( Z)âR , âC( Z)âC( Z)R , âCH âNHR , âCH âZR , âCH âSOR , âCH âSO R , âCF âOR , âNHâCH R , âZâCH R , âSOâCH R , âSO âCH R , âOâCF R , âOâC( Z)R , âN NâR , âNHâSO R , âSO âNR R , âCZâCZâNHR , âNHâCOâOR , âOâCOâNHR , âNHâCOâNHR , âR , âCX CX R , âC( NOR ), â(CH ) R , âCH âCOâNH(CH ) R , âCH âNHâCO(CH ) R , âCH âCOâCH R , âC( NR )âNH(CH ) R , âC(X ) Nâ(CH ) R or âCH(X )âCH R ; A represents a direct bond, or a straight or branched C alkylene chain optionally substituted by hydroxyl, alkoxy, oxo, cycloalkyl, aryl or heteroaryl, or A represents a straight or branched C alkenylene or C alkynylene chain; Z represents a direct bond, an oxygen or sulphur atom or NH; n and m each represent zero or 1, provided that n is 1 when m is zero and n is zero when m is 1; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.

US Patent:

6821280, Nov 23, 2004

Filed:

Aug 3, 2000

Appl. No.:

09/631502

Inventors:

Charanpreet S. Bagga - Malvern PA 19355
Eric Gray - Rockford MN 55373
John E. Regan - Brentwood CA 90049

International Classification:

A61B 1702

US Classification:

606 80, 606 61

Abstract:

An instrument for cutting and/or curetting during surgery is discosed. The instruments of the invention are particularly advantageous for use in removing disc material from an intervertebral disc space. In a preferred embodiment, rotation of the instrument around a longitudinal axis of the instrument provides for intermittently distracting vertebrae adjacent to the intervertebral disc space during rotation.

US Patent:

7329675, Feb 12, 2008

Filed:

Sep 1, 2004

Appl. No.:

10/933077

Inventors:

Paul Joseph Cox - Flemington NJ, US
Shelley Bower - Bedminster NJ, US
David John Aldous - Gillette NJ, US
Peter Charles Astles - Kent, GB
Daniel Gerard McGarry - Branchburg NJ, US
Christopher Hulme - Phoenixville PA, US
John Robinson Regan - Larchmont NY, US
Fu-Chih Huang - Belle Mead NJ, US
Stevan Wakefield Djuric - Libertyville PA, US
Kevin Joseph Moriarty - Norristown PA, US
Rose Mappilakunnel Mathew - Collegeville PA, US
Gregory Bernard Poli - Bethlehem PA, US

Assignee:

Aventis Pharma Limited - West Malling

International Classification:

A61K 31/44
A61K 43/40
C07D 405/00

US Classification:

5142844, 514339, 5462821

Abstract:

This invention is directed to physiologically active compounds of formula (I)Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmnaceutical compositions comprising compoundS of formula (I), their phatmaceUtical use and methods for their preparation.

US Patent:

8178568, May 15, 2012

Filed:

Jun 24, 2009

Appl. No.:

13/002659

Inventors:

John Regan - Larchmont NY, US
Doris Riether - Newtown CT, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim am Rhein

International Classification:

A61K 31/422
A61K 31/4015
A61K 31/4025
C07D 207/12

US Classification:

514380, 548245, 548246, 548518, 548543, 514422, 514424

Abstract:

Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

US Patent:

20010039290, Nov 8, 2001

Filed:

Mar 14, 2001

Appl. No.:

09/808084

Inventors:

John Regan - Larchmont NY, US
Eugene Hickey - Danbury CT, US
Neil Moss - Ridgefield CT, US
Charles Cywin - Bethel CT, US
Christopher Pargellis - West Redding CT, US
Thomas Gilmore - Middlebury CT, US

International Classification:

C07D257/04
C07D233/04
C07D233/54
C07D231/10

US Classification:

514/381000, 514/383000, 514/399000, 514/407000, 514/408000, 548/267200, 548/254000, 548/338100, 548/375100, 548/567000

Abstract:

Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are therefore useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

US Patent:

20050234091, Oct 20, 2005

Filed:

Mar 4, 2005

Appl. No.:

11/072819

Inventors:

John Regan - Larchmont NY, US
Thomas Lee - Danbury CT, US
David Thomson - Ridgefield CT, US
Thomas Kirrane - Southbury CT, US
Daniel Kuzmich - Danbury CT, US
John Proudfoot - Newtown CT, US
Younes Bekkali - Danbury CT, US
Renee Zindell - Danbury CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07D471/02
C07D491/02
C07D498/02
A61K031/4745
A61K031/4743
A61K031/4741

US Classification:

514300000, 514301000, 546114000, 546122000, 514302000, 546115000

Abstract:

Compounds of Formula (I) wherein R, R, R, R, R, Rand X are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

US Patent:

48639575, Sep 5, 1989

Filed:

Dec 21, 1987

Appl. No.:

7/135805

Inventors:

Kent W. Neuenschwander - Ambler PA
John R. Regan - Princeton NJ
Benedict J. Kosmider - Audubon PA

Assignee:

Rorer Pharmaceutical Corporation - Fort Washington PA

International Classification:

A61K 31365
C07D30920

US Classification:

514460

Abstract:

Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof. Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.