John Michael Sharp

US Patent:

20020182675, Dec 5, 2002

Filed:

Oct 25, 2001

Appl. No.:

10/042431

Inventors:

Sean McCarthy - San Diego CA, US
Christopher Fraser - Lexington MA, US
John Sharp - Arlington MA, US
Thomas Barnes - Brookline MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12P021/02
C12N005/06
C07K014/435
C07H021/04
C12N009/00

US Classification:

435/069100, 435/183000, 435/320100, 435/325000, 530/350000, 536/023200

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20030170621, Sep 11, 2003

Filed:

Jan 19, 2001

Appl. No.:

09/766511

Inventors:

Sean McCarthy - San Diego CA, US
Christopher Fraser - Lexington MA, US
John Sharp - Arlington MA, US
Thomas Barnes - Brookline MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Jamaica Plain MA, US
Nicholas Wrighton - Winchester MA, US
Andrew Goodearl - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Mehran Khodadoust - Brookline MA, US

International Classification:

C12Q001/68
C07H021/04
C12N009/00
C12P021/02
C12N005/06

US Classification:

435/006000, 435/069100, 435/183000, 435/320100, 435/325000, 536/023200

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20070048771, Mar 1, 2007

Filed:

Jul 21, 2006

Appl. No.:

11/491318

Inventors:

Sean McCarthy - San Diego CA, US
Christopher Fraser - Lexington MA, US
John Sharp - Arlington MA, US
Thomas Barnes - Brookline MA, US
Susan Kirst - Brookline MA, US
Paul Myers - Jamaica Plain MA, US
Nicholas Wrighton - Winchester MA, US
Andrew Goodearl - Natick MA, US
Douglas Holtzman - Jamaica Plain MA, US
Mehran Khodadoust - Brookline MA, US

International Classification:

C12Q 1/68
G01N 33/53
C07H 21/04
C12P 21/06
C07K 14/705

US Classification:

435006000, 435007100, 435320100, 435069100, 435325000, 530350000, 536023500

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20090136959, May 28, 2009

Filed:

Oct 23, 2008

Appl. No.:

12/288775

Inventors:

Sean A. McCarthy - San Diego CA, US
Christopher C. Fraser - Lexington MA, US
John D. Sharp - Arlington MA, US
Thomas M. Barnes - Brookline MA, US
Susan J. Kirst - Brookline MA, US
Paul S. Myers - Jamaica Plain MA, US
Nicholas Wrighton - Winchester MA, US
Andrew D.J. Goodearl - Natick MA, US
Douglas A. Holtzman - Jamaica Plain MA, US
Mehran Khodadoust - Brookline MA, US

International Classification:

C12Q 1/68
C12N 15/11
C12N 15/00
C12N 5/06
C07K 14/00
G01N 33/00
C07K 1/00
C07K 16/18
C12P 21/04
G01N 33/53

US Classification:

435 6, 536 231, 4353201, 435325, 530350, 5303879, 435 691, 435 72, 435375, 435402, 436 86

Abstract:

The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

US Patent:

20210046350, Feb 18, 2021

Filed:

Nov 3, 2020

Appl. No.:

17/088084

Inventors:

Vincent Matthew Antunez - Schertz TX, US
John T. Sharp - Selma TX, US

International Classification:

A63B 21/06
A63B 21/00
A63B 21/065
A63B 23/04
A63B 23/035
A63B 21/16

Abstract:

A tire exercise system has a tire having an interior portion covered with an inner tire cover. At least four shoulder strap attachment points are attached to the tire and configured to secure a right and left shoulder strap. At least two handles are attached to the tire and configured to accommodate human hands. At least two anchors are attached to the tire and configured to accommodate a rope system. A waist harness includes a waist belt. An anchor is attached to the waist belt. A rope system is attached to the tire and the waist harness. The rope system includes a first carabiner attached to a bungee cord, which can then be attached to the tire. A ring is attached to the bungee cord. A rope is attached to the ring. A second carabiner is attached to the rope, which can then be attached to the waist harness.

US Patent:

20190224518, Jul 25, 2019

Filed:

Mar 29, 2019

Appl. No.:

16/370798

Inventors:

Vincent Matthew Antunez - Schertz TX, US
John T. Sharp - Selma TX, US

International Classification:

A63B 21/06
A63B 21/00
A63B 21/065
A63B 23/04
A63B 23/035
A63B 21/16

Abstract:

A tire exercise system has a tire having an interior portion covered with an inner tire cover. At least four shoulder strap attachment points are attached to the tire and configured to secure a right and left shoulder strap. At least two handles are attached to the tire and configured to accommodate human hands. At least two anchors are attached to the tire and configured to accommodate a rope system. A waist harness includes a waist belt. An anchor is attached to the waist belt. A rope system is attached to the tire and the waist harness. The rope system includes a first carabiner attached to a bungee cord, which can then be attached to the tire. A ring is attached to the bungee cord. A rope is attached to the ring. A second carabiner is attached to the rope, which can then be attached to the waist harness.

US Patent:

20180140885, May 24, 2018

Filed:

Sep 14, 2017

Appl. No.:

15/704659

Inventors:

Vincent Matthew Antunez - Schertz TX, US
John T. Sharp - Selma TX, US

International Classification:

A63B 21/06
A63B 21/00
A63B 21/065
A63B 21/16
A41F 9/02
A63B 23/035

Abstract:

A tire exercise system has a tire having an interior portion covered with an inner tire cover. At least four shoulder strap attachment points are attached to the tire and configured to secure a right and left shoulder strap. At least two handles are attached to the tire and configured to accommodate human hands. At least two anchors are attached to the tire and configured to accommodate a rope system. A waist harness includes a waist belt. An anchor is attached to the waist belt. A rope system is attached to the tire and the waist harness. The rope system includes a first carabineer attached to a bungee cord, which can then be attached to the tire. A ring is attached to the bungee cord. A rope is attached to the ring. A second carabineer is attached to the rope, which can then be attached to the waist harness.