John X Sheehan

US Patent:

8413136, Apr 2, 2013

Filed:

May 8, 2009

Appl. No.:

12/437691

Inventors:

Kristofer Reierson - Acton MA, US
Feroz Gora - Walpole MA, US
Charles Kossi Kekeh - Melrose MA, US
Peter A. Morgan - Allston MA, US
Joseph W. Rovine - Boston MA, US
John M. Sheehan - Cambridge MA, US
Lidiya Vikhlyayeva - Revere MA, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06F 9/445
G06F 13/00

US Classification:

717174, 710 3

Abstract:

A virtual application packaged for a specific executing environment may be executed on a processing device having an executing environment different from the specific executing environment. A reference, included in extracted installer metadata, to one or more key paths of a hierarchically-structured data store may be modified according to a set of rules related to the executing environment detected in the processing device. The modified extracted installer metadata may be provided to an installer for installing the virtual application. During execution of the virtual application, a request to read, write, or modify the hierarchically-structured data store may be intercepted and changed, such that a first key path included in the request may be mapped to a second key path, based on the detected executing environment. Similarly, a response to the request, which may include the second key path, may be intercepted and modified, to the first key path.

US Patent:

20110219365, Sep 8, 2011

Filed:

Mar 5, 2010

Appl. No.:

12/717969

Inventors:

Leib Adam Foxman - Reading MA, US
Neil Jacobson - Arlington MA, US
Eric C. Jewart - Waltham MA, US
Alp Emre Kanlikilicer - Cambridge MA, US
John M. Sheehan - Cambridge MA, US
Jeremy E. Dunker - Boston MA, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06F 9/44
G06F 9/445

US Classification:

717168, 717174

Abstract:

A set of high value state in application state for a software application can be distinguished from a set of low value state in the application state. For example, a set of heuristics can be run on the application state to distinguish between the set of high value state and the set of low value state. A set of designations that designate the set of high value state in the application state as high value and that designate the set of low value state in the application state as low value can be generated. When processing the application, the high value state can be processed differently than the low value state. The application may be packaged as a virtual application.

US Patent:

43813003, Apr 26, 1983

Filed:

Feb 3, 1981

Appl. No.:

6/231260

Inventors:

John C. Sheehan - Lexington MA
Thomas J. Commons - Boston MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D50157
A61K 31545

US Classification:

424246

Abstract:

Biologically active sulfur analogs of 6-aminopenicillanic acid having a nucleophile substituted in the 6- position are made by reacting a sulfenyl chloride with esters of diazopenicillanic acid. Biologically active sulfur analogs of 7-aminocephalosporanic acid having a nucleophile substituted in the 7- position are analogously made by reacting a sulfenyl chloride with esters of 7-diazocephalosporanic acid. Deacetoxycephalosporins can be formed from the corresponding analog of 6-aminopenicillanic acid and derivations thereof, by sulfoxide rearrangement of the thiazolidine ring of penicillins to the dihydrothiazine ring of cephalosporins. These nucleophile substituted sulfur analogs of penicillins and cephalosporins are new antibacterial agents and display antibacterial activity against a variety of microorganisms.

US Patent:

43615147, Nov 30, 1982

Filed:

Feb 17, 1981

Appl. No.:

6/234979

Inventors:

John C. Sheehan - Lexington MA
Young S. Lo - Boston MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D49900
A61K 31425

US Classification:

2602452R

Abstract:

In accordance with this invention, it has been found that carbon and oxygen analogs of 6. beta. -aminopenicillanic acid and biologically active derivatives thereof can be formed from esters of 6-oxopenicillanic acid. For example, 6. beta. -phenoxyacetoxypenicillanic acid--an oxygen analog of penicillin V and 6. beta. -phenoxyacetylmethylpenicillanic acid--a carbon analog of penicillin V, may be formed from an ester of 6-oxopenicillanate. The ester of 6-oxopenicillanic acid is formed by a diiospropyl carbodiimide/dimethyl sulfoxide oxidation of the corresponding ester of 6. alpha. -hydroxypenicillanic acid. The oxygen analogs are formed by reducing the ester of 6-oxopenicillanic acid to the corresponding 6. beta. -hydroxypenicillanate and then forming the desired analog by acylation. The carbon analogs are formed by a Wittig reaction of the ester of 6-oxopenicillanic acid with a suitable acylmethylenetriphenylphosphorane followed by saturation of the newly formed double bond and removal of the protective ester group.

US Patent:

39391515, Feb 17, 1976

Filed:

Jul 25, 1974

Appl. No.:

5/491873

Inventors:

John C. Sheehan - Lexington MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D50124

US Classification:

260243C

Abstract:

This invention relates to a new, biologically active material conforming to the formula ##SPC1## The material is formed by a process comprising displacement of the thiazolidine ring in Pencillin V and formation of the cephem system.

US Patent:

42658829, May 5, 1981

Filed:

Oct 3, 1977

Appl. No.:

5/838874

Inventors:

John C. Sheehan - Lexington MA
Thomas J. Commons - Boston MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D49900

US Classification:

424114

Abstract:

Biologically active sulfur analogs of 6-aminopenicillanic acid having a nucleophile substituted in the 6-position are made by reacting a sulfenyl chloride with esters of diazopenicillanic acid. Biologically active sulfur analogs of 7-aminocephalosporanic acid having a nucleophile substituted in the 7-position are analogously made by reacting a sulfenyl chloride with esters of 7-diazocephalosporanic acid. Deacetoxycephalosporins can be formed from the corresponding analog of 6-aminopenicillanic acid and derivations thereof, by sulfoxide rearrangement of the thiazolidine ring of penicillins to the dihydrothiazine ring of cephalosporins. These nucleophile substituted sulfur analogs of penicillins and cephalosporins are new antibacterial agents and display antibacterial activity against a variety of microorganisms.

US Patent:

46223940, Nov 11, 1986

Filed:

Dec 2, 1977

Appl. No.:

5/856749

Inventors:

John C. Sheehan - Lexington MA
Young S. Lo - Boston MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D50100
A61K 31545

US Classification:

540228

Abstract:

In accordance with this invention, it has been found that the oxygen analog of 7-amino-cephalosporanic acid and biologically active derivatives thereof can be formed from esters of 7-amino-cephalosporanic acid. Esters of 7-oxocephalosporanic acid can be formed by diazotization of an ester or 7-amino-cephalosporanic acid and contact of the diazo compound so formed with a hypohalous acid and a base in a water miscible organic solvent. Oxygen analogs of 7-aminocephalosporins isolated as esters are then formed by reducing the aforesaid ester to the corresponding 7. beta. -hydroxy-cephalosporanate and then forming the desired analog by introduction of a side chain via hydroxyl group modification. Oxygen analogs of 7-amino-cephalosporins are then formed by regeneration of the acid via protective group removal.

US Patent:

41430468, Mar 6, 1979

Filed:

Mar 21, 1977

Appl. No.:

5/779828

Inventors:

John C. Sheehan - Lexington MA
Young S. Lo - Boston MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D27704

US Classification:

2603067C

Abstract:

In accordance with this invention, it has been found that carbon and oxygen analogs of 6. beta. -aminopenicillanic acid and biologically active derivatives thereof can be formed from esters of 6-oxopenicillanic acid. For example, 6. beta. -phenoxyacetoxypenicillanic acid -- an oxygen analog of penicillin V and 6. beta. -phenoxyacetylmethylpenicillanic acid -- a carbon analog of penicillin V, may be formed from an ester of 6-oxopenicillanate. The ester of 6-oxopenicillanic acid is formed by a diiospropyl carbodiimide/dimethyl sulfoxide oxidation of the corresponding ester of 6. alpha. -hydroxypenicillanic acid. The oxygen analogs are formed by reducing the ester of 6-oxopenicillanic acid to the corresponding 6. beta. -hydroxypenicillanate and then forming the desired analog by acylation. The carbon analogs are formed by a Wittig reaction of the ester of 6-oxopenicillanic acid with a suitable acylmethylenetriphenylphosphorane followed by saturation of the newly formed double bond and removal of the protective ester group.