John William Smart

US Patent:

6440929, Aug 27, 2002

Filed:

Apr 26, 2001

Appl. No.:

09/744777

Inventors:

Sam J. Milstein - Larchmont NY
John E. Smart - Katonah NY
Donald J. Sarubbi - Carmel NY
Monica Leipold - Thornwood NY
Elizabeth Flanders - Ridgefield CT
Doris OToole - Carmel NY
David Gschneidner - Stamford CT

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A61K 3800

US Classification:

514 2, 514 3, 514 11, 514 12, 514 21, 514 56, 514563

Abstract:

The present invention relates to pulmonary delivery of active agents. Acylated or sufonated amino acids are used as carriers to facilitate pulmonary delivery of active agents to a target.

US Patent:

6627228, Sep 30, 2003

Filed:

Oct 9, 2001

Appl. No.:

09/889005

Inventors:

Sam J. Milstein - Larchmont NY
Eugene N. Barantsevitch - Scarsdale NY
Nai Fang Wang - Long Island City NY
Jun Liao - Tarrytown NY
John E. Smart - Katonah NY
Richard D. Conticello - Ossining NY
Raphael M. Ottenbrite - Midlothian VA

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A61K 914

US Classification:

424489, 424 7816, 424451, 424452, 424464, 424465

Abstract:

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

6693073, Feb 17, 2004

Filed:

Jun 14, 2002

Appl. No.:

10/172582

Inventors:

Sam J. Milstein - Larchmont NY
John E. Smart - Katonah NY
Donald J. Sarubbi - Carmel NY
Monica Leipold - Thornwood NY
Elizabeth Flanders - Ridgefield CT
Doris OToole - Carmel NY
David Gschneidner - Stamford CT

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A61K 3828

US Classification:

514 3, 514 2, 514 11, 514 12, 514 21, 514 56, 514563

Abstract:

The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.

US Patent:

7208483, Apr 24, 2007

Filed:

May 28, 2003

Appl. No.:

10/447608

Inventors:

Sam J. Milstein - Larchmont NY, US
Eugene N. Barantsevitch - Scarsdale NY, US
Nai Fang Wang - Long Island City NY, US
Jun Liao - Tarrytown NY, US
John E. Smart - Katonah NY, US
Richard D. Conticello - Ossining NY, US
Raphael M. Ottenbrite - Midlothian VA, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

A07N 43/30

US Classification:

514166, 514159, 424400

Abstract:

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

7727558, Jun 1, 2010

Filed:

Jan 31, 2007

Appl. No.:

11/669649

Inventors:

Sam J. Milstein - Larchmont NY, US
Eugene N. Barantsevitch - Scarsdale NY, US
Nai Fang Wang - Long Island City NY, US
Jun Liao - Yorktown Heights NY, US
John Smart - Katonah NY, US
Richard Conticello - Ossining NY, US
Raphael Ottenbrite - Midlothian VA, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY
Virginia Commonwealth University - Richmond VA

International Classification:

A61K 9/50

US Classification:

424501

Abstract:

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

20050176627, Aug 11, 2005

Filed:

Mar 9, 2005

Appl. No.:

11/075957

Inventors:

Anthony Cerami - Somers NY, US
John Smart - Palmetto FL, US
Michael Brines - Woodbridge CT, US
Carla Cerami - Sleepy Hollow NY, US

International Classification:

A61K038/18
C07K014/505

US Classification:

514008000, 530397000

Abstract:

Methods for increasing the hematocrit of an individual while maintaining the tissue protective activities of endogenous erythropoietin through the administration of a pharmaceutical compound containing chemically modified long acting erythropoietin. Also disclosed are the new chemically modified long acting erythropoietins, methods of producing the chemically modified long acting erythropoietins, and compositions comprising the chemically modified long acting erythropoietins.

US Patent:

51497883, Sep 22, 1992

Filed:

Oct 24, 1988

Appl. No.:

7/261198

Inventors:

Pascal Bailon - Florham Park NJ
John E. Smart - Weston MA
David V. Weber - Nutley NJ

Assignee:

Hoffmann-La Roche, Inc. - Nutley NJ

International Classification:

C07K 1500
C07K 320
C07K 1700
G01N 3350

US Classification:

530350

Abstract:

Methods are provided for the purification of interleukin-2 (IL-2) and chimeric proteins containing an IL-2 moiety from a wide variety of sources, including synthetic mixtures, cell culture conditioned medium and mammalian and bacterial recombinant expression systems. The methods of the invention employ IL-2 receptor-affinity adsorbents in which soluble IL-2 receptors have been immobilized on solid supports. Through the use of these affinity adsorbents, highly purified IL-2 and chimeric proteins containing an IL-2 moiety can be produced in a single step from bacterial extracts or conditioned medium. The proteins thus purified are largely free of aggregated forms, which are often present when other purification methods are used.

US Patent:

51625032, Nov 10, 1992

Filed:

May 19, 1987

Appl. No.:

7/051967

Inventors:

Pascal Bailon - Florham Park NJ
John E. Smart - Weston MA
David V. Weber - Nutley NJ

Assignee:

Hoffmann-La Roche, Inc. - Nutley NJ

International Classification:

C07K 1500
C07K 320
C07K 1700
G01N 3350

US Classification:

5303882

Abstract:

Methods are provided for the purification of interleukin-2 (IL-2) from a wide variety of sources, including synthetic mixtures, culture medium conditioned by natural IL-2 producing cells, and mammalian and bacterial recombinant IL-2 expression systems. The methods of the invention employ IL-2 receptor-affinity adsorbents in which soluble IL-2 receptors have been immobilized on solid supports. Through the use of these affinity adsorbents, highly purified IL-2 can be produced in a single step from bacterial extracts or conditioned medium. The IL-2 thus purified is largely free of aggregated forms, which are often present when other purification methods are used.