John C Spiridigliozzi

US Patent:

6379373, Apr 30, 2002

Filed:

Sep 3, 1999

Appl. No.:

09/390046

Inventors:

Amarpreet S. Sawhney - Lexington MA
John Spiridigliozzi - Boston MA

Assignee:

Confluent Surgical, Inc. - Waltham MA

International Classification:

A61M 2900

US Classification:

606193

Abstract:

Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

US Patent:

6387977, May 14, 2002

Filed:

Jul 14, 2000

Appl. No.:

09/616256

Inventors:

Amarpreet S. Sawhney - Lexington MA
David A. Melanson - Hudson NH
Chandrashekar P. Pathak - Lexington MA
Jeffrey A. Hubbell - San Marino CA
Luis Z. Avila - Arlington MA
Mark T. Kieras - Newburyport MA
Stephen D. Goodrich - Woburn MA
Shikha P. Barman - Lowell MA
Arthur J. Coury - Boston MA
Ronald S. Rudowsky - Sudbury MA
Douglas J. K. Weaver - Bedford MA
Marc A. Levine - Fremont CA
John C. Spiridigliozzi - Dedham MA
Thomas S. Bromander - Andover MA
Dean M. Pichon - Concord MA
George Selecman - Marblehead MA
David J. Nedder - Attleboro MA
Bradley C. Poff - White Bear Lake MN
Donald L. Elbert - Pasadena CA

Assignee:

Focal, Inc. - Lexington MA
Board of Regents, The University of Texas System - Austin TX

International Classification:

C09D 400

US Classification:

522184, 522185, 424487, 602904, 523111, 523114, 523118

Abstract:

An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as âprimingâ. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, âprimingâ can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other.

US Patent:

6689148, Feb 10, 2004

Filed:

Nov 21, 2001

Appl. No.:

09/990883

Inventors:

Amarpreet S. Sawhney - Lexington MA
John Spiridigliozzi - Boston MA

Assignee:

Incept LLC - Lexington MA

International Classification:

A61M 2900

US Classification:

606193

Abstract:

Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

US Patent:

7220270, May 22, 2007

Filed:

Jan 13, 2004

Appl. No.:

10/756181

Inventors:

Amarpreet S. Sawhney - Lexington MA, US
John Spiridigliozzi - Boston MA, US

Assignee:

Incept LLC - Lexington MA

International Classification:

A61M 29/00

US Classification:

606193

Abstract:

Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

US Patent:

7320703, Jan 22, 2008

Filed:

Mar 11, 2005

Appl. No.:

11/077890

Inventors:

Kristian DiMatteo - Waltham MA, US
Robert Thistle - Brockton MA, US
John Spiridigliozzi - Hyde Park MA, US

International Classification:

A61F 2/06

US Classification:

623 112, 623903

Abstract:

A graft system for intraluminal delivery in a vessel in need of repair comprising a graft, anchoring means, and a strippable sheath around at least part of the graft. A preferred anchoring means is a balloon-expandable stent. Also included in the invention is a method of using the device to treat a body lumen. The strippable sheath is removable by pulling on a drawstring to remove it which permits expansion of the graft. The positioning of the device may then be adjusted prior to stent dilation. A preferred embodiment of the invention includes a bifurcated graft system for intraluminal delivery in an aortic aneurysm comprising a bifurcated graft having a distal region and two legs, an expandable stent disposed in part of the distal region, and a strippable crocheted sheath around the distal region and one of the two legs. The strippable crocheted sheath is removable by untying it to permit expansion of the graft after initial placement within the aneurysm.

US Patent:

7510571, Mar 31, 2009

Filed:

Aug 19, 2003

Appl. No.:

10/643315

Inventors:

John Spiridigliozzi - Sharon MA, US
William R. Quinn - Swampscott MA, US
Ryan Cahill - Holmdel NJ, US

Assignee:

Boston Scientific, SCIMED, Inc. - Maple Grove MN

International Classification:

A61F 2/06

US Classification:

623 128, 623 113

Abstract:

A composite multilayer implantable material having a first inner tubular layer formed of expanded polytetrafluoroethyene having a porous microstructure defined by nodes interconnected by fibrils, wherein said first layer has a plurality of pleated folds, a second tubular layer formed of textile material circumferentially disposed exteriorly to said first layer; and having an elastomeric bonding agent applied to one of said first layer or second layer and disposed within the pores of said microstructure for securing said first layer to said second layer.

US Patent:

7588596, Sep 15, 2009

Filed:

Dec 29, 2004

Appl. No.:

11/025020

Inventors:

John Spiridigliozzi - Sharon MA, US
Ilya Yampolski - West Roxbury MA, US

Assignee:

Scimed Life Systems, Inc. - Maple Grove MN

International Classification:

A61F 2/06

US Classification:

623 116, 623 135

Abstract:

An endoluminal prosthesis for treatment of a condition in a lumen in the vicinity of a branch lumen, the lumen being adapted to resist migration, is provided. In one embodiment, the prosthesis includes a substantially tubular main stent adapted for placement in the main lumen. A substantially tubular anchor stent is connected to the main stent and adapted for placement in the branch lumen.

US Patent:

7628806, Dec 8, 2009

Filed:

Aug 20, 2003

Appl. No.:

10/643261

Inventors:

Ilya Yampolsky - W. Roxbary MA, US
John Spiridigliozzi - Sharon MA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61F 2/06

US Classification:

623 135

Abstract:

A bifurcated stent comprises a trunk region and at least one branch. The trunk region has a balloon expandable section and a self-expandable section. The balloon expandable section is less compressible than the self-expandable section. The branch is self-expandable and extends from the self-expandable section of the trunk region. The balloon expandable section is less compressible than the branch.