John W Triplett

US Patent:

42567270, Mar 17, 1981

Filed:

Sep 18, 1978

Appl. No.:

5/943555

Inventors:

John W. Triplett - Lexington KY
Randall B. Smith - Lexington KY

Assignee:

The University of Kentucky Research Foundation - Lexington KY

International Classification:

A61K 4900
A61K 4300
G01T 3348
G01T 100

US Classification:

424 15

Abstract:

A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with. sup. 76 Br,. sup. 77 Br or. sup. 82 Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either. sup. 76 Br. sub. 2,. sup. 77 Br. sub. 2 or. sup. 82 Br. sub. 2. This is a substitution type of reaction in which a ring hydrogen is substituted by either. sup. 76 Br,. sup. 77 Br or. sup. 82 Br.

US Patent:

44487630, May 15, 1984

Filed:

Nov 10, 1980

Appl. No.:

6/205423

Inventors:

John W. Triplett - Lexington KY

Assignee:

The University of Kentucky Research Foundation - Lexington KY

International Classification:

A61K 4300
A61K 4900

US Classification:

424 11

Abstract:

Radiopharmaceutical compositions and methods for tumor tomography in mammals are disclosed, wherein radioactive gallium and non-radioactive indium are injected into said mammals whereby the affinity of said radioactive gallium for non-tumor tissues is decreased, resulting in enhanced imaging characteristics.