The invention provides mutated, cytotoxic forms of exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
System And Method For Crowdsourcing Event-Related Social Media Posts
Approaches for facilitating crowdsourcing of event-related social media posts are disclosed. In certain implementations, a first post that includes information specifying a first meteorological event may be received from a first user. Information specifying a first location associated with the first post may be obtained. A determination of whether the first location is within a predetermined proximity threshold of a second location associated with a second post that includes information specifying the first meteorological event may be effectuated. The first post may be presented to one or more other users in response to a determination that the first location is not within the predetermined proximity threshold.
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which express mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
Dr. Weldon graduated from the Medical College of Georgia School of Medicine in 1984. He works in Pascagoula, MS and specializes in Internal Medicine. Dr. Weldon is affiliated with Ocean Springs Hospital and Singing River Hospital.
Assistant Professor, Department of Biological Sciences at Towson University
Location:
Baltimore, Maryland Area
Industry:
Higher Education
Work:
Towson University - Towson, MD since Aug 2012
Assistant Professor, Department of Biological Sciences
National Cancer Institute - Bethesda, MD Feb 2006 - Aug 2012
Research Fellow
Foundation for Advanced Education in the Sciences - Bethesda, MD Sep 2008 - May 2012
Instructor
National Eye Institute, NIH - Bethesda, MD Jun 1994 - Aug 2000
Summer Student
Education:
The Johns Hopkins University 2000 - 2005
Ph.D., Biology
St. Mary's College of Maryland 1996 - 2000
B.A., Biology
Georgetown Preparatory School 1992 - 1996
High School
Awards:
Fellows Award for Research Excellence (FARE) 2009 National Institutes of Health (NIH) Recognition for outstanding scientific research performed by NIH intramural postdoctoral fellows.
https://www.training.nih.gov/felcom/fare Pharmacology Research Associate (PRAT) Fellow (2006-2009) National Institute of General Medical Sciences (NIGMS) The longstanding NIGMS PRAT Program is a competitive postdoctoral fellowship program to pursue research in one of the laboratories of the National Institutes of Health (NIH) or the Food and Drug Administration (FDA). The program was initiated to address a national need for well-trained pharmacologists, and as the field of pharmacology has matured and broadened, the program has followed suit. To reflect this shift, in 2012 the P in the program’s acronym changed from “Pharmacology” to “Postdoctoral.” The PRAT acronym remains the same.
http://www.nigms.nih.gov/Training/PRAT.htm Federal Technology Transfer Award (2009-2011) National Institutes of Health A cash award that recognizes scientific, engineering and technical personnel for inventions, innovations, computer software, or other outstanding scientific or technological contributions of value to the United States due to commercial application or contributions to the missions of NIH, HHS and/or the Federal Government, or for exemplary activities that promote the domestic transfer of science and technology development within the Federal Government resulting in use by American industry or business, universities, State or local governments, or other non-Federal parties.
Black Rock Elementary School Bridgeport CT 1976-1980, Longfellow Middle School Bridgeport CT 1980-1984, High Horizons Elementary School Bridgeport CT 1984-1986