John P Weldon

US Patent:

20100215656, Aug 26, 2010

Filed:

Sep 4, 2008

Appl. No.:

12/676203

Inventors:

Ira H. Pastan - Bethesda MD, US
John Weldon - Bethesda MD, US
David FitzGerald - Bethesda MD, US

International Classification:

A61K 39/395
C07K 14/21
C07K 16/12
C07H 21/04
A61P 35/00

US Classification:

4241341, 530350, 5303873, 536 237, 536 2353

Abstract:

The invention provides mutated, cytotoxic forms of exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.

US Patent:

20140195625, Jul 10, 2014

Filed:

Jan 8, 2014

Appl. No.:

14/150305

Inventors:

John Christopher Weldon - Arlington VA, US

International Classification:

H04L 12/58

US Classification:

709206

Abstract:

Approaches for facilitating crowdsourcing of event-related social media posts are disclosed. In certain implementations, a first post that includes information specifying a first meteorological event may be received from a first user. Information specifying a first location associated with the first post may be obtained. A determination of whether the first location is within a predetermined proximity threshold of a second location associated with a second post that includes information specifying the first meteorological event may be effectuated. The first post may be presented to one or more other users in response to a determination that the first location is not within the predetermined proximity threshold.

US Patent:

20140154248, Jun 5, 2014

Filed:

May 4, 2012

Appl. No.:

14/115131

Inventors:

Ira H. Pastan - Potomac MD, US
John Weldon - Columbia MD, US
Richard Beers - Rockville MD, US

Assignee:

The United States of America,as represented by the Secretary, Department of Health and Human Service - Bethesda MD

International Classification:

C07K 16/30
C07K 14/21

US Classification:

4241341, 5303873, 536 234, 4353201, 43525233, 530350, 4352542, 435328

Abstract:

Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to improved recombinant immunotoxins comprising anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and a Exotoxin moiety which has been modified to reduce its immunogenicity and protease sensitivity and providing a better cytotoxicity for cells which express mesothelin. The RITs are well-suited for the treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.