John D Wille

US Patent:

6670395, Dec 30, 2003

Filed:

Oct 22, 1997

Appl. No.:

08/954946

Inventors:

John J. Wille - Trenton NJ

Assignee:

Bristol-Myers Squibb Company - New York NY

International Classification:

A61K 31235

US Classification:

514543, 514568

Abstract:

Methods, compositions and systems for preventing an adverse reaction of the skin to the presence of a skin-sensitizing and/or skin-irritating agent by administering an effective amount of phenoxyacetic acid and/or a lower alkyl ester thereof to a warm blooded animal.

US Patent:

7399493, Jul 15, 2008

Filed:

Jul 18, 2005

Appl. No.:

11/183495

Inventors:

John J. Wille - Trenton NJ, US

International Classification:

A61K 36/899

US Classification:

424750

Abstract:

Anti-irritant botanical extracts, and a method for screening, and then preparing, anti-irritant botanical extracts for use in topical formulations, providing a natural ingredient capable of preventing skin irritation when in combination with other active and inactive ingredients that have the potential to irritant skin.

US Patent:

20050048020, Mar 3, 2005

Filed:

Jun 22, 2004

Appl. No.:

10/873590

Inventors:

John Wille - Trenton NJ, US

International Classification:

A61K007/06
A61K007/11
A61K007/075
A61K007/08

US Classification:

424070130, 424070240

Abstract:

A thixotropic microemulsion for the treatment of mammalian skin; and methods for the preparation thereof; and skin treatment formulations formed therefrom. The delivery system is an oil-in-water type emulsion that is especially useful as a vehicle for the delivery of hydrophobic and hydroalcoholic plant extracts having anti-irritant and/or anti-oxidant properties. The delivery system is comprised of natural, hydrophobic, chemically-modified type starches and polysaccharaides. Among the oils preferred in this embodiment are: mineral oil, petrolatum jelly and silicone oils, either added singly or in various combinations. Among surfactants employed as emulsifiers are: either a cationic detergent, e.g., benzalkonium chloride, an anionic, e.g., sodium lauryl sulfate, and a non-ionic detergent, e.g., Triton X-100 or combinations of oils and surfactants. The resulting emulsion is a semi-viscous and thixotropic gel, which is stable upon prolonged standing at ambient storage temperature.

US Patent:

20060165749, Jul 27, 2006

Filed:

Jan 25, 2006

Appl. No.:

11/339419

Inventors:

John Wille - Trenton NJ, US

International Classification:

A01N 25/00
A61K 36/18
A61K 8/18
A61K 9/50
A61K 9/16

US Classification:

424405000, 424725000, 424490000, 424065000

Abstract:

A method of sequestering volatile fragrances by encapsulating them in the oil phase of a thixotropic microemulsion, and drying to a thin film, and subsequently releasing the volatile oils upon rehydration of the dried film; compositions comprising the volatile fragrances encapsulated in the oil phase of a thixotropic microemulsion, which compositions may also contain temperature sensitive ingredients; and a wound dressing comprising a dried film formed from a thixotropic microemulsion.

US Patent:

20060213815, Sep 28, 2006

Filed:

Jan 30, 2006

Appl. No.:

11/342469

Inventors:

John Wille - Trenton NJ, US

International Classification:

C10G 21/02

US Classification:

208324000

Abstract:

Methods and compositions for suppression hydrocarbon fumes, and cooking oil fumes, by applying a non-volatile organic compounds having a vapor pressure temperature greater than the vapor pressure temperature of the hydrocarbon fume constituents, or cooking oil fume constituents; said compositions may include delivery vehicles such as 70% ethanol, or thixotropic lotions, to produce remediation formulations that may be sprayed or spread onto the surfaces from which the fumes are emanating; also included is an insect repellant, comprising non-volatile organic compounds having a vapor pressure temperature greater than the vapor pressure temperature of the human pheromones and body odors with attract biting insects.

US Patent:

20070042026, Feb 22, 2007

Filed:

Mar 17, 2005

Appl. No.:

11/083178

Inventors:

John Wille - Trenton NJ, US

International Classification:

A61F 13/02
A61K 36/898

US Classification:

424448000, 424766000

Abstract:

Botanically derived anti-irritants for prophylactic and therapeutic treatment of adverse skin reactions from application of transdermal or topical drug delivery system, permits the effective administration of a drug from a delivery system in which the drug, of a component of the delivery system comprises a skin irritant; and the delivery systems formed thereby.

US Patent:

20080003190, Jan 3, 2008

Filed:

Jun 22, 2007

Appl. No.:

11/821288

Inventors:

John Wille - Chesterfield NJ, US

International Classification:

A61K 8/97
A61K 36/53
A61P 31/00
C12Q 1/02
C12Q 1/18
A61Q 15/00
A61K 36/82

US Classification:

424065000, 424729000, 424745000, 424774000, 424776000, 424778000, 435029000, 435032000

Abstract:

A method is disclosed for the preparation of an antimicrobial botanical active from a natural plant. The method comprises the steps of:

US Patent:

20080152609, Jun 26, 2008

Filed:

Nov 30, 2007

Appl. No.:

11/998698

Inventors:

John Jacob Wille - Chesterfield NJ, US

International Classification:

A61K 8/65
A61Q 5/04

US Classification:

424 705

Abstract:

A method is disclosed for suppressing low vapor pressure sulfurous fumes generated by sulfur-containing organic compounds, such as is found in personal hair care products. The method includes the step of applying a liquid with a higher vapor pressure temperature than the sulfur-containing compounds to materials contaminated with the sulfur-containing organic compounds.