Jon A. DODD - Littleton CO, US Thomas G. DILORENZO - Arvada CO, US Frank CORBIN - Littleton CO, US
Assignee:
CARIDIANBCT, INC. - Lakewood CO
International Classification:
C12N 5/02 C12M 1/00
US Classification:
435383, 4352891
Abstract:
A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a bioreactor all fluidly interconnected. The premounted fluid conveyance assembly is adapted to be detachably-attached to the cell expansion machine. Accordingly, after a premounted fluid conveyance assembly is used, it is removed from the cell expansion machine by disengaging it from the cell expansion machine. Thereafter, another premounted fluid conveyance assembly can be attached in place of the previously used premounted fluid conveyance assembly.
Rotation System For Cell Growth Chamber Of A Cell Expansion System And Method Of Use Therefor
Paul M. Leuthaeuser - Louisville CO, US Jon A. Dodd - Littleton CO, US Thomas G. DiLorenzo - Arvada CO, US
Assignee:
CARIDIANBCT, INC. - Lakewood CO
International Classification:
C12N 5/071 C12M 1/10
US Classification:
435394, 4352891
Abstract:
A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip.
Configurable Methods And Systems Of Growing And Harvesting Cells In A Hollow Fiber Bioreactor System
Glen Delbert ANTWILER - Lakewood CO, US Patrick J. HOWLEY - Highlands Ranch CO, US Michael E. KINZIE - Lafayette CO, US Jon A. DODD - Littleton CO, US Casey V. MEDINA - Westminster CO, US
Assignee:
CARIDIANBCT, INC. - Lakewood CO
International Classification:
G06F 3/048 G06F 3/041 C12M 1/00
US Classification:
345173, 4352891, 715780
Abstract:
Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
Methods And Systems Of Growing And Harvesting Cells In A Hollow Fiber Bioreactor System With Control Conditions
Thomas G. DILORENZO - Arvada CO, US Glen Delbert ANTWILER - Lakewood CO, US Michael E. KINZIE - Lafayette CO, US Brian J. Nankervis - Thornton CO, US Monique Givens - Westminster CO, US Casey V. Medina - Westminster CO, US Jon A. Dodd - Littleton CO, US
Assignee:
CARIDIANBCT, INC. - Lakewood CO
International Classification:
C12Q 3/00 C12M 1/36
US Classification:
435 3, 4352865
Abstract:
Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
Customizable Methods And Systems Of Growing And Harvesting Cells In A Hollow Fiber Bioreactor System
Glen Delbert ANTWILER - Lakewood CO, US Patrick J. HOWLEY - Highlands Ranch CO, US Michael E. KINZIE - Lafayette CO, US Jon A. DODD - Littleton CO, US Casey V. Medina - Westminster CO, US
Assignee:
CARIDIANBCT, INC. - Lakewood CO
International Classification:
G06F 3/048
US Classification:
715763
Abstract:
Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
Rotation System For Cell Growth Chamber Of A Cell Expansion System And Method Of Use Therefor
Jon A. DODD - Littleton CO, US Thomas G. DILORENZO - Arvada CO, US
Assignee:
Terumo BCT, Inc. - Lakewood CO
International Classification:
C12N 5/00
US Classification:
435394, 4352982
Abstract:
A system and method for rotating a cell growth chamber of a cell expansion system includes a rotatable member for engaging a chamber coupling attached to the cell growth chamber. The rotatable member includes an independently operable mechanism for engaging a rotatable fitting associated with the chamber coupling. In at least one embodiment, the chamber coupling is selectively rotatable by turning the rotatable member, thereby rotating the cell growth chamber around a first axis. The cell growth chamber is also selectively rotatable around a second axis by turning the rotatable fitting associated with the chamber coupling. Other novel aspects include a way of attaching the cell growth chamber to the shaft assembly, and a new tube routing clip.
Biological Component Cassette, Biological Component Kit, And Biological Component Treatment System
- TOKYO, JP - LAKEWOOD CO, US Jon DODD - Littleton CO, US
International Classification:
A61M 1/02 C12M 1/00 C12M 3/00
Abstract:
A biological component cassette includes a cassette main body having a flow path for the liquid in an interior of the cassette main body. The cassette main body is flexible and has a sheet-like shape. The biological component cassette includes a frame that is less flexible than the cassette main body. The frame includes an accommodation chamber in which the cassette main body is accommodated. A side portion of the frame forms at least part of the accommodation chamber. When the cassette main body is accommodated in the accommodation chamber, one surface of the cassette main body is covered by a bottom portion of the accommodation chamber, and another surface of the cassette main body is exposed to an external environment.
Configurable Methods And Systems Of Growing And Harvesting Cells In A Hollow Fiber Bioreactor System
- Lakewood CO, US Glen Delbert ANTWILER - Lakewood CO, US Patrick J. HOWLEY - Highlands Ranch CO, US Michael E. KINZIE - Lafayette CO, US Jon A. DODD - Littleton CO, US Casey V. MEDINA - Westminster CO, US
International Classification:
C12M 1/34 C12M 3/00 C12M 1/12 C12M 1/00 C12M 1/36
Abstract:
Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.