Jonathan High Roth

US Patent:

20180305430, Oct 25, 2018

Filed:

Jan 29, 2018

Appl. No.:

15/882919

Inventors:

- Cambridge MA, US
David C. Litzinger - San Diego CA, US
Soumitra S. Ghosh - Cambridge MA, US
Zijian Guo - Cambridge MA, US
Caroline Ekblad - Cambridge MA, US
Jonathan D. Roth - Cambridge MA, US

International Classification:

C07K 14/575
C07K 14/315
A61K 38/22
A61K 38/00

Abstract:

Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.