Jonathan L Sessler

US Patent:

6375930, Apr 23, 2002

Filed:

Nov 20, 1997

Appl. No.:

08/975090

Inventors:

Stuart W. Young - Portola CA
Meredith Wright - San Jose CA
Jonathan L. Sessler - Austin TX
Tarak D. Mody - Sunnyvale CA
Darren Magda - Cupertino CA

Assignee:

Board of Regents, The University of Texas System - Austin TX
Pharmacyclics, Inc. - Sunnyvale CA

International Classification:

A61B 55055

US Classification:

424 9362, 424 111, 424 165, 424 91, 424 93, 424450, 546 11, 544 1, 540 1, 540145

Abstract:

Compositions having a texaphyrin-lipophilic molecule conjugate loaded into a biological vesicle and methods for imaging, diagnosis and treatment using the loaded vesicle are provided. For example, liposomes or red blood cells loaded with a paramagnetic texaphyrin-lipophilic molecule conjugate have utility as a blood pool contrast agent, facilitating the enhancement of normal tissues, magnetic resonance angiography, and marking areas of damaged endothelium by their egress through fenestrations or damaged portions of the blood vascular system. Liposomes or cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate can be photolysed, allowing for a photodynamic therapy effect at the site of lysis. Availability of red blood cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate provides a method for delivering a photodynamic therapeutic agent to a desired site with a high concentration of oxygen. By presenting the agent in this way, it is expected that a patient will experience less toxicity.

US Patent:

6482949, Nov 19, 2002

Filed:

May 26, 2000

Appl. No.:

09/579040

Inventors:

Jonathan Sessler - Austin TX 78731
Bruno Andrioletti - 94800 Villejuif, FR
Andrew Carl Try - Croydon, NSW, 2132, AU
Christopher Black - Round Rock TX 78681

International Classification:

C07D40314

US Classification:

544343, 544344, 544353, 544354, 544355, 544356

Abstract:

The present invention provides novel compounds exemplified by pyrrolic nitrogens used as anion and neutral species recognition elements with an aromatic core as a signal group. Described are methods for the synthesis of various pyrrole aryl compounds as well as various applications for these compounds. Methods of use include the binding and detection of specific analytes in a mixture and, in some examples, the separation of the analyte from the mixture. Additional methods of use include the transport of therapeutic agents and the sensing of components, degradants, and impurities in foodstuffs.

US Patent:

6608196, Aug 19, 2003

Filed:

May 3, 2002

Appl. No.:

10/138032

Inventors:

Bing Wang - Cupertino CA
Satyanarayana Janagani - Santa Clara CA
Wyeth B. Callaway - Austin TX
Jonathan L. Sessler - Austin TX

Assignee:

Galileo Pharmaceuticals, Inc. - Santa Clara CA

International Classification:

C07D41300

US Classification:

544130, 544162, 544171, 544365, 544399, 546208, 546226, 546242, 546246, 548569, 560 17, 560168, 562440, 564162, 564163, 564194

Abstract:

Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

US Patent:

6657058, Dec 2, 2003

Filed:

Oct 18, 2002

Appl. No.:

10/274776

Inventors:

Darren Magda - Cupertino CA
Jonathan L. Sessler - Austin TX
Sharon Hannah - Vancouver, CA

Assignee:

Pharmacyclics, Inc. - Sunnyvale CA
Board of Regents, University of Texas System - Austin TX

International Classification:

C07D48716

US Classification:

540472

Abstract:

The present invention provides a process of synthesizing a compound of Formula I by treating, in an inert medium and in the presence of an organic base, a compound of formula A with an organo metallic agent capable of acting as an outer sphere oxidant to form a compound of Formula I.

US Patent:

6825186, Nov 30, 2004

Filed:

Oct 27, 2000

Appl. No.:

09/699027

Inventors:

Jonathan L. Sessler - Austin TX
Darren Magda - Cupertino CA

Assignee:

Pharmacyclics, Inc. - Sunnyvale CA
Board of Regents, University of Texas System - Austin TX

International Classification:

C07D48712

US Classification:

514185, 540472, 540465, 540145, 514410

Abstract:

The radiation sensitization potential of a candidate compound can be screened by determine its ability to generate one or more reactive oxygen species under appropriate conditions. Compounds determined to have radiation sensitization potential are employed in methods for treating atheroma, tumors and other neoplastic tissue as well as other conditions that typically responsive to radiation sensitization.

US Patent:

6984734, Jan 10, 2006

Filed:

Feb 26, 2003

Appl. No.:

10/373949

Inventors:

Jonathan L. Sessler - Austin TX, US
Daniel Seidel - Cambridge MA, US
Frederic R. Bolze - Strasbourg, FR
Thomas Koehler - Austin TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 245/00
G02F 1/035
G11B 7/24
B32B 3/26

US Classification:

540460, 540451, 540455, 540468, 540470, 540476, 385 2, 43027015, 43027016, 4283044

Abstract:

The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where n is 6, 7, 8, 9, 10, 11, or 12, and derivatives, multimers, isomers, and ion and neutral molecule complexes thereof as new compositions of matter. A protonated form of cyclo[n]pyrrole displays a gap of up to 700 nm between strong Soret and Q-like absorption bands in the electronic spectrum, demonstrating no significant ground state absorption in the visible portion of the electronic spectrum. Uses of cyclo[n]pyrroles as separation media, nonlinear optical materials, information storage media and infrared filters are provided.

US Patent:

7041819, May 9, 2006

Filed:

Aug 24, 2001

Appl. No.:

09/939514

Inventors:

Jonathan L. Sessler - Austin TX, US
Manuel Marquez - Lincolnshire IL, US
Pavel Anzenbacher, Jr. - Bowling Green OH, US
James A. Shriver - Austin TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C07D 487/22

US Classification:

540145

Abstract:

The present invention provides halogenated calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles having 4–12 pyrrolic rings with greater stability, enhanced anion and neutral molecule binding affinity, and different binding selectivites as compared to their non-halogenated congeners as judged from H NMR, F NMR and fluorescence emission spectroscopic analyses.

US Patent:

7109188, Sep 19, 2006

Filed:

Sep 23, 2004

Appl. No.:

10/950302

Inventors:

Jonathan L. Sessler - Austin TX, US
Darren Magda - Cupertino CA, US

Assignee:

Pharmacyclics, Inc. - Sunnyvale CA
Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 31/40
A61K 31/409

US Classification:

514185, 514410, 540472, 540465, 540145

Abstract:

Injectible formulations comprising motexafin gadolinium are described herein.