Jonathan M Mills

US Patent:

20110236340, Sep 29, 2011

Filed:

Aug 22, 2009

Appl. No.:

13/060207

Inventors:

Paul Mansky - San Francisco CA, US
Detlef Albrecht - Saratoga CA, US
Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Campbell CA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

Assignee:

Relypsa, Inc. - Santa Clara CA

International Classification:

A61K 31/78
A61P 3/02
A61P 13/12
A61P 9/10

US Classification:

424 781

Abstract:

The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.