Jorge A Carrasquillo

US Patent:

51851423, Feb 9, 1993

Filed:

Jul 28, 1989

Appl. No.:

7/386095

Inventors:

Steven M. Larson - Washington DC
Ronald Finn - Bethesda MD
Jorge A. Carrasquillo - Rockville MD
James C. Reynolds - Rockville MD
Ronald D. Neumann - Potomac MD
Martin C. Graham - Larchmont NY
Keith S. Pentlow - Forest Hills NY

Assignee:

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC

International Classification:

A61K 4902
C07K 1500

US Classification:

424 11

Abstract:

A composition comprises an antigen-specific antibody or antigen-binding fragment thereof labeled with Iodine-124 at a site other than, and which does not significantly interfere with, the antibody-antigen binding site. An in vivo method of radiotherapy directed to an antigenic site comprises administering to a subject in need of the therapy an amount of the antigen-specific composition described above effective to attain a reduction of the size of a tumor associated with the antigen. An in vivo method for detecting and localizing an antigenic site in a subject in need of such detection comprises administering to the subject an amount of the antigen-specific composition of the invention effective to localize the antigen-antibody binding site and scanning the subject's body with a positron-emitter detector to attain the localization of the site. An in situ method of radiotherapy directed to an antigenic site in a subject in need of such therapy comprises detecting and localizing the site by the in vivo method described above and thereafter in situ delivering a positron-emitting labeled antibody chelate capable of binding to either the I-124 labeled antibody or fragment thereof, or to the antigen at a site other than the antibody-antigen binding site.