Josef Mayer Miller from 2401 Vinewood Blvd, Ann Arbor, MI 48104, age 87

Isbn (Books And Publications)

Cochlear Implants: Models of the Electrically Stimulated Ear

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Author
Josef M. Miller

ISBN #
0387970339

Cochlear Implants: Models of the Electrically Stimulated Ear

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Author
Josef M. Miller

ISBN #
3540970339

Resumes

Josef Miller

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Us Patents

Auditory Nerve Protection And Re-Growth
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US Patent:

7700111, Apr 20, 2010
Filed:

Jan 16, 2003
Appl. No.:

10/345731
Inventors:

Josef M. Miller - Ann Arbor MI, US
Richard A. Altschuler - Ann Arbor MI, US
Yehoash Raphael - Ann Arbor MI, US
Assignee:

The Regents of the University of Michigan - Ann Arbor MI
International Classification:

A61F 13/00
A61K 39/00
A61N 1/00
US Classification:

4241981, 424422, 607 57
Abstract:

The present invention relates to compositions and methods for the protection and restoration of hearing. In particular, the present invention relates to treatments to facilitate the protection and re-growth of the auditory nerve. The present invention further provides methods of preventing hair cell loss and the accompanying loss in hearing. The present invention thus provides novel interventions for a variety of hearing impairments.

Prevention Of Cisplatin Induced Deafness
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US Patent:

7700134, Apr 20, 2010
Filed:

Jan 16, 2003
Appl. No.:

10/345802
Inventors:

Goran Laurell - Stockholm, SE
Andreas Ekborn - Stockholm, SE
Josef Miller - Ann Arbor MI, US
Hans Ehrsson - Stockholm, SE
Assignee:

The Regents of the University of Michigan - Ann Arbor MI
International Classification:

A61K 33/24
A01N 47/28
A61K 31/17
US Classification:

424659, 514580
Abstract:

The present invention relates to compositions and methods for the protection and restoration of hearing. In particular, the present invention relates to methods and compositions for the prevention of chemical (e. g. , cisplatin) induced deafness. The present invention thus provides methods of improving the outcome of subjects treated with cisplatin.

Composition And Method Of Treating Hearing Loss
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US Patent:

7786100, Aug 31, 2010
Filed:

Mar 20, 2006
Appl. No.:

11/384579
Inventors:

Josef Miller - Ann Arbor MI, US
Daisuke Yamashita - Yokohama, JP
Assignee:

The Regents of the University of Michigan - Ann Arbor MI
International Classification:

A61K 31/355
A61K 31/60
A61P 27/16
US Classification:

514159, 514458, 514164
Abstract:

A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.

Composition And Method Of Treating Hearing Loss
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US Patent:

7951845, May 31, 2011
Filed:

Jan 17, 2007
Appl. No.:

11/623888
Inventors:

Josef Miller - Ann Arbor MI, US
Colleen LePrell - Ypsilanti MI, US
Jochen Schacht - Ann Arbor MI, US
Diane Prieskorn - Livonia MI, US
Assignee:

The Regents of the University of Michigan - Ann Arbor MI
International Classification:

A61K 31/07
A61K 31/245
A61K 31/60
A61K 8/19
A61P 27/16
US Classification:

514725, 514458, 514474, 514733, 381 60
Abstract:

A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.

Composition And Method Of Treating Hearing Loss
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US Patent:

8053424, Nov 8, 2011
Filed:

Jul 19, 2010
Appl. No.:

12/839245
Inventors:

Josef Miller - Ann Arbor MI, US
Daisuke Yamashita - Yokohama, JP
Assignee:

The Regents of the University of Michigan - Ann Arbor MI
International Classification:

A61K 31/60
A61P 27/16
US Classification:

514161, 514159, 514458
Abstract:

A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is greater than the effect of the individual components alone. The composition includes a biologically effective amount of vitamin E for inhibiting propagation of lipid peroxidation that contributes to hearing loss. The composition also includes a biologically effective amount of a salicylate for reducing hydroxyl radicals that contribute to hearing loss. A method of treating hearing loss includes the step of internally administering the composition, as described above, to a mammal within three days of trauma to a middle or inner ear of the mammal. In other words, the composition is effective even when administered as late as three days after trauma to a middle or inner ear of a mammal.

Composition And Method Of Treating Side Effects From Antibiotic Treatment
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US Patent:

8338397, Dec 25, 2012
Filed:

Apr 15, 2010
Appl. No.:

12/761121
Inventors:

Josef Miller - Ann Arbor MI, US
Assignee:

The Regents of the University of Michigan - Ann Arbor MI
International Classification:

A61K 33/06
A61K 31/355
A61K 31/60
A61K 31/07
A61K 31/375
A61K 31/245
US Classification:

514171, 514458, 514474, 514725, 514733, 424682
Abstract:

A method of treating side effects of antibiotic treatment includes the step of internally administering an antibiotic that is capable of inducing hearing loss in a mammal. The method further includes the step of internally administering a composition to the mammal in conjunction with administration of the antibiotic. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, vitamin E, vitamin C, and a vasodilator comprising magnesium. The combination of vitamins and the vasodilator comprising magnesium, in the biologically effective amounts, provides an effective treatment for treating side effects of antibiotic treatment.

Composition And Method Of Treating Hearing Loss
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US Patent:

8338398, Dec 25, 2012
Filed:

Apr 21, 2011
Appl. No.:

13/091931
Inventors:

Josef Miller - Ann Arbor MI, US
Colleen LePrell - Ypsilanti MI, US
Jochen Schact - Ann Arbor MI, US
Diane Prieskorn - Livonia MI, US
Assignee:

The Regents of the University of Michigan - Ann Arbor MI
International Classification:

A61K 33/06
A61K 31/355
A61K 31/60
A61K 31/07
A61K 31/375
A61K 31/245
US Classification:

514171, 514733, 514458, 514725, 514474, 424682
Abstract:

A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.

Composition And Method Of Treating Temporary And Permanent Hearing Loss
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US Patent:

20090155390, Jun 18, 2009
Filed:

Nov 21, 2008
Appl. No.:

12/313527
Inventors:

Josef M. Miller - Ann Arbor MI, US
Colleen G. Le Prell - Gainesville FL, US
D. Clark Bennett - Portage MI, US
Peter A. Boxer - Dexter MI, US
International Classification:

A61K 33/00
US Classification:

424722
Abstract:

A composition for treating permanent and temporary hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.