Joseph A Barbi

US Patent:

20190077855, Mar 14, 2019

Filed:

Feb 10, 2017

Appl. No.:

16/077368

Inventors:

- Baltimore MD, US
Duojia Pan - Dallas TX, US
Drew M. Pardoll - Brookeville MD, US
Joseph Barbi - East Amherst NY, US
Juan Fu - Lutherville MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C07K 16/22
A61P 35/00
A61P 17/06
A61P 19/02
A61K 31/7105
A61K 38/17

Abstract:

The present invention relates to compositions and methods for treating cancer by targeting the Activin signaling pathway. In certain embodiments, combining Activin blockade with immunomodulation alters regulatory T (Treg) cell-mediated immune regulation and treats cancer.

US Patent:

20190046583, Feb 14, 2019

Filed:

Feb 10, 2017

Appl. No.:

16/077411

Inventors:

- Baltimore MD, US
Duojia Pan - Dallas TX, US
Drew M. Pardoll - Brookeville MD, US
Joseph Barbi - East Amherst NY, US
Juan Fu - Lutherville MD, US

Assignee:

Johns Hopkins Technology Ventures - Baltimore MD

International Classification:

A61K 35/30
A61K 38/41
G01N 33/68
G01N 33/58
C12N 5/074
C12N 5/00

Abstract:

The present invention relates to novel compositions and methods to produce 3D organ equivalents of the brain (i.e. “mini-brains”). The invention also relates to methods of using human induced pluripotent stem cells, a combination of growth and other soluble factors and gyratory shaking. Cells from healthy or diseased donors or animals can be used to allow testing different genetic backgrounds. The model can be further enhanced by using genetically modified cells, adding micro-glia or their precursors or indicator cells (e.g. with reporter genes or tracers) as well as adding endothelial cells to form a blood-brain-barrier.