Joseph V Boykin

US Patent:

20010048915, Dec 6, 2001

Filed:

Jun 21, 2001

Appl. No.:

09/885410

Inventors:

Joseph Boykin - Chester VA, US

International Classification:

A61K049/00

US Classification:

424/009310

Abstract:

Wound healing is impaired in many diabetics, who suffer increased risk of chronic foot ulceration and amputation. Diabetic patients with poor healing ability were found to possess significantly lower fasting urinary nitrate levels than diabetic patients with normal healing ability or non-diabetic controls, implicating decreased endogenous nitric oxide activity as the mediator of diabetes-impaired wound healing. Methods and kits are provided for predicting the wound healing ability of diabetic patients based on the levels of nitric oxide related products such as nitrate or nitrite in urine or other specimens. Methods are also provided for treating non-wound healing diabetics and monitoring diabetic ulcer treatment.

US Patent:

20030134332, Jul 17, 2003

Filed:

Nov 8, 2002

Appl. No.:

10/290496

Inventors:

Joseph Boykin - Chester VA, US

International Classification:

G01N033/53
C12Q001/26
A61K048/00
A61K031/353
A61K031/375
A61K031/355

US Classification:

435/007100, 435/025000, 514/044000, 514/456000, 514/458000, 514/474000, 436/116000

Abstract:

Methods and kits are provided for diagnosing medical conditions of patients with a disease or condition characterized by endothelial dysfunction based on a nitric oxide bioactivity index. Nitric oxide bioactivity index is the ratio of the level of a nitric oxide-related product such as nitrate or nitrite to the level of an oxidant stress-related product such as isoprostane in plasma, urine, or another specimen from a patient. Methods are also provided for using the nitric oxide bioactivity index to treat patients with endothelial dysfunction and monitor the course of treatment.

US Patent:

20040112375, Jun 17, 2004

Filed:

Nov 20, 2003

Appl. No.:

10/716657

Inventors:

Joseph Boykin - Chester VA, US

International Classification:

A62B009/00

US Classification:

128/200240

Abstract:

Methods and kits are provided for determining whether a patient will respond favorably to hyperbaric oxygen therapy treatment. The method comprises the step of comparing nitric oxide production, a nitric oxide-related product level, and/or the nitric oxide bioactivity index in a specimen from a patient with a threshold value. If nitric oxide production, nitric oxide-related product level, and/or the nitric oxide bioactivity index (defined as “the level of a nitric oxide-related product to the level of an oxidant stress-related product”) is above the threshold value then the patient will respond favorably to hyperbaric oxygen therapy treatment. If nitric oxide production, nitric oxide-related product level, and/or the nitric oxide bioactivity index is approximately at or below the threshold value then the patient may not respond favorably to hyperbaric oxygen therapy treatment.

US Patent:

6312663, Nov 6, 2001

Filed:

Mar 1, 2000

Appl. No.:

9/516584

Inventors:

Joseph V. Boykin - Chester VA

International Classification:

A61K 4900

US Classification:

424 931

Abstract:

Wound healing is impaired in many diabetics, who suffer increased risk of chronic foot ulceration and amputation. Diabetic patients with poor healing ability were found to possess significantly lower fasting urinary nitrate levels than diabetic patients with normal healing ability or non-diabetic controls, implicating decreased endogenous nitric oxide activity as the mediator of diabetes-impaired wound healing. Methods and kits are provided for predicting the wound healing ability of diabetic patients based on the levels of nitric oxide related products such as nitrate or nitrite in urine or other specimens. Methods are also provided for treating non-wound healing diabetics and monitoring diabetic ulcer treatment.

US Patent:

20010047035, Nov 29, 2001

Filed:

Feb 6, 2001

Appl. No.:

09/776926

Inventors:

Joseph Boykin - Chester VA, US

International Classification:

A61K033/00
A61K031/198
A61K031/21

US Classification:

514/509000, 424/718000, 514/565000

Abstract:

Wound healing is impaired in many diabetics, who suffer increased risk of chronic foot ulceration and amputation. Diabetic patients with poor healing ability were found to possess significantly lower fasting urinary nitrate levels than diabetic patients with normal healing ability or non-diabetic controls, implicating decreased endogenous nitric oxide activity as the mediator of diabetes-impaired wound healing. Methods and kits are provided for predicting the wound healing ability of diabetic patients and patients with venous stasis ulceration or another disease or condition characterized by chronically impaired cutaneous wound healing in some patients based on the levels of nitric oxide related products such as nitrate or nitrite in urine or other specimens. Methods are also provided for treating non-wound healing patients and monitoring diabetic ulcer treatment.

Address:

12600 Nightingale Dr, Chester, VA 23836

VIN:

5J6RE48797L012944

Make:

HONDA

Model:

CR-V

Year:

2007