Joseph Thomas Bruder

US Patent:

6391612, May 21, 2002

Filed:

Oct 27, 1999

Appl. No.:

09/428507

Inventors:

Joseph T. Bruder - Ijamsville MD
Imre Kovesdi - Rockville MD
Alena Lizonova - Gaithersburg MD

Assignee:

GenVec, Inc. - Gaithersburg MD

International Classification:

C12P 1934

US Classification:

4352351, 4353201, 435 9133, 435325, 435410, 536 231

Abstract:

The present invention provides a method of in vitro propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i. e. , a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e. g. , a mammalian, host-production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.

US Patent:

6440944, Aug 27, 2002

Filed:

Oct 16, 1998

Appl. No.:

09/174508

Inventors:

Joseph T. Bruder - Frederick MD
Imre Kovesdi - Rockville MD

Assignee:

GenVec, Inc. - Gaithersburg MD

International Classification:

A61K 4800

US Classification:

514 44, 4353201, 435455, 435 691, 435 696, 424 931, 4241991, 4242331

Abstract:

The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic neutralizing antibodies to neutralize the adenoviral gene transfer vector outside a targeted muscle. Another method involves the repeat administration of an adenoviral gene transfer vector to a skeletal muscle.

US Patent:

6455314, Sep 24, 2002

Filed:

Sep 10, 1999

Appl. No.:

09/393627

Inventors:

Thomas J. Wickham - Falls Church VA
Imre Kovesdi - Rockville MD
Petrus W. Roelvink - Olney MD
Joseph T. Bruder - Ijamsville MD

Assignee:

GenVec, Inc. - Gaithersburg MD

International Classification:

C12N 1586

US Classification:

435456, 4352351, 4353201, 435325, 435 697, 435 691, 530350, 530300, 530402, 536 231, 536 234, 536 241

Abstract:

The present invention provides a recombinant protein having an amino terminus of an adenoviral fiber protein and having a trimerization domain. A fiber incorporating such a protein exhibits reduced affinity for a native substrate than does a wild-type adenoviral fiber trimer. The present invention further provides an adenovirus incorporating the recombinant protein of the present invention.

US Patent:

6472176, Oct 29, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/736743

Inventors:

Imre Kovesdi - Rockville MD
Joseph T. Bruder - Ijamsville MD

Assignee:

GenVec, Inc. - Gaithersburg MD

International Classification:

C12P 2100

US Classification:

435 691, 4353201, 435 697, 435 698, 435455, 435325, 536 231, 536 232, 536 234, 536 235, 536 237, 536 241

Abstract:

The invention pertains to a polynucleotide encoding a chimeric protein comprising an endoplasmic reticulum localization signal peptide, a transport moiety, and a moiety of interest, wherein the endoplasmic reticulum localization signal peptide, the transport moiety, and the moiety of interest are operably linked with each other, a vector comprising the polynucleotide, a cell comprising such a vector, and a method of expressing a protein comprising the transport moiety and the moiety of interest.

US Patent:

6482616, Nov 19, 2002

Filed:

May 27, 1999

Appl. No.:

09/321797

Inventors:

Imre Kovesdi - Rockville MD
Douglas E. Brough - Olney MD
Duncan L. McVey - Derwood MD
Joseph T. Bruder - New Market MD
Alena Lizonova - Rockville MD

Assignee:

GenVec, Inc. - Gaithersburg MD

International Classification:

C12N 510

US Classification:

435 914, 4353201, 435325, 435366, 435456

Abstract:

The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.

US Patent:

6576456, Jun 10, 2003

Filed:

Jun 4, 1999

Appl. No.:

09/326447

Inventors:

Thomas J. Wickham - Bethesda MD
Erik Falck-Pedersen - Dobbs Ferry NY
Petrus W. Roelvink - Gaithersburg MD
Joseph T. Bruder - New Market MD
Jason Gall - New York NY
Imre Kovesdi - Rockville MD

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY
GenVec, Inc. - Gaithersburg MD

International Classification:

C12N 701

US Classification:

4352351, 530324, 530350, 4353201, 536 231, 536 234, 536 2372

Abstract:

The invention provides a chimeric adenovirus fiber protein including a nonnative amino acid sequence, and a chimeric adenovirus fiber protein lacking a native amino acid receptor-binding sequence. The chimeric protein trimerizes when produced in a mammalian cell.

US Patent:

6596270, Jul 22, 2003

Filed:

Apr 16, 2001

Appl. No.:

09/835683

Inventors:

Joseph T. Bruder - Ijamsville MD
Imre Kovesdi - Rockville MD

Assignee:

GenVec, Inc. - Gaithersburg MD

International Classification:

A61K 3500

US Classification:

424 932, 514 44, 4353201, 435325, 424 691, 424 931, 4241991, 4242331

Abstract:

The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic neutralizing antibodies to neutralize the adenoviral gene transfer vector outside a targeted muscle. Another method involves the repeat administration of an adenoviral gene transfer vector to a skeletal muscle.

US Patent:

6756044, Jun 29, 2004

Filed:

Jul 17, 2000

Appl. No.:

09/617569

Inventors:

Petrus W. Roelvink - Olney MD
Joseph T. Bruder - Ijamsville MD
Imre Kovesdi - Rockville MD
Thomas J. Wickham - Germantown MD

Assignee:

GenVec, Inc. - Gaithersburg MD

International Classification:

A61K 4500

US Classification:

4242811, 4241441, 4241841, 4242331, 4242781, 4352351, 5303882

Abstract:

The present invention provides a complex that includes a virion having a ligand that recognizes an epitope present on an immune effector cell surface and at least a first nucleic acid encoding a first non-native antigen. The invention also provides a library including a plurality of such complexes, in which antigens of at least two of the plurality are different. Using such reagents, the invention provides a method of precipitating an immune response within an immune effector cell, wherein such a complex is delivered to the cell under conditions sufficient for the cell to mount an immune response to the antigen. When applied in vivo, the method can serve to immunize an animal from the pathogen. Moreover, using a library including a plurality of complexes, which contains at least one test antigen, the invention provides a method of assessing the antigenicity of the test antigen.