Joseph Macnaughton Curtis

US Patent:

58247807, Oct 20, 1998

Filed:

Jun 6, 1995

Appl. No.:

8/470173

Inventors:

Joseph Edward Curtis - Glendora CA
Sam Leland Helgerson - Pasadena CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61K 3514

US Classification:

530383

Abstract:

A method for preparing a purified and stable activated human Factor VIII composition is disclosed. A purified and stable activated human Factor VIII composition having a specific activity of at least 100,000 units per mg protein, or a potency of at least 15,000 units per ml is also disclosed.

US Patent:

55762913, Nov 19, 1996

Filed:

Sep 13, 1993

Appl. No.:

8/120894

Inventors:

Joseph E. Curtis - Glendora CA
Sam L. Helgerson - Pasadena CA
Roger L. Lundblad - Chapel Hill NC

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61K 3836
A61K 3837
C07K 14745
C07K 14755

US Classification:

514 12

Abstract:

Stabilized and activated Factor VIII is used as a therapeutic agent to treat patients with a Factor VIII deficiency. This includes hemophilia A patients as well as patients with Factor VIII inhibitors which block the hemostatic activity of Factor VIII. The stabilized and activated Factor VIII is also prepared in a therapeutic composition with a therapeutically acceptable adjuvant.