Joseph Eugene Drumm

US Patent:

7495014, Feb 24, 2009

Filed:

Jan 29, 2004

Appl. No.:

10/767638

Inventors:

Paul S. Charifson - Framingham MA, US
David D. Deininger - Arlington MA, US
Anne-Laure Grillot - Cambridge MA, US
Yusheng Liao - Lexington MA, US
Steven M. Ronkin - Watertown MA, US
Dean Stamos - Framingham MA, US
Emanuele Perola - Cambridge MA, US
Tiensheng Wang - Concord MA, US
Arnaud LeTiran - Ashland MA, US
Joseph Drumm - Westborough MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/44
C07D 401/04
C07D 401/14

US Classification:

514338, 514221, 5142278, 5142345, 514255, 514256, 514269, 514318, 514394, 540291, 544 81, 544124, 544132, 544280, 544281, 544282, 544319, 544370, 544380, 546193, 5462734, 5483027, 5483044

Abstract:

The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

US Patent:

7569591, Aug 4, 2009

Filed:

Jul 29, 2004

Appl. No.:

10/901928

Inventors:

Paul S. Charifson - Framingham MA, US
David D. Deininger - Arlington MA, US
Anne-Laure Grillot - Cambridge MA, US
Yusheng Liao - Lexington MA, US
Steven M. Ronkin - Watertown MA, US
Dean Stamos - Framingham MA, US
Emanuele Perola - Cambridge MA, US
Tiansheng Wang - Concord MA, US
Arnaud LeTiran - Lexington MA, US
Joseph Drumm - Westborough MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/4439
C07D 401/00

US Classification:

514338, 514333, 514256, 5462744, 546256, 544335

Abstract:

The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

US Patent:

7582641, Sep 1, 2009

Filed:

Nov 11, 2004

Appl. No.:

10/986569

Inventors:

Paul S. Charifson - Framingham MA, US
David D. Deininger - Arlington MA, US
Anne-Laure Grillot - Cambridge MA, US
Yusheng Liao - Lexington MA, US
Steven M. Ronkin - Watertown MA, US
Dean Stamos - Framingham MA, US
Emanuele Perola - Cambridge MA, US
Tiansheng Wang - Concord MA, US
Arnaud LeTiran - Lexington MA, US
Joseph Drumm - Westborough MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/506
C07D 239/26

US Classification:

514256, 544296, 544333

Abstract:

The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.

US Patent:

7618974, Nov 17, 2009

Filed:

Oct 21, 2004

Appl. No.:

10/971573

Inventors:

Paul Charifson - Framingham MA, US
David Deininger - Arlington MA, US
Anne-Laure Grillot - Cambridge MA, US
Yusheng Liao - Lexington MA, US
Steven M. Ronkin - Watertown MA, US
Dean P. Stamos - Framingham MA, US
Emanuele Perola - Cambridge MA, US
Tiansheng Wang - Concord MA, US
Arnaud LeTiran - Lexington MA, US
Joseph Drumm - Westborough MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/506
C07D 403/04

US Classification:

514256, 544333

Abstract:

The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

US Patent:

7727992, Jun 1, 2010

Filed:

Jun 11, 2003

Appl. No.:

10/459420

Inventors:

Paul S. Charifson - Framingham MA, US
David D. Deininger - Arlington MA, US
Joseph Drumm - Westborough MA, US
Anne-Laure Grillot - Cambridge MA, US
Yusheng Liao - Lexington MA, US
Patricia Oliver-Shaffer - Acton MA, US
Dean Stamos - Framingham MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 239/42
A61K 31/505
A61K 31/44
C07D 239/00
C07D 401/00

US Classification:

514256, 514269, 514338, 544242, 544298, 5462734

Abstract:

The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.

US Patent:

8034832, Oct 11, 2011

Filed:

Jun 4, 2009

Appl. No.:

12/478372

Inventors:

Paul Charifson - Framingham MA, US
David Deininger - Waltham MA, US
Anne-Laure Grillot - Somerville MA, US
Yusheng Liao - Lexington MA, US
Steven Ronkin - Watertown MA, US
Dean Stamos - Carlsbad CA, US
Emanuele Perola - Brookline MA, US
Tiansheng Wang - Concord MA, US
Arnaud LeTiran - Lexington MA, US
Joseph Drumm - Westborough MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 401/00
A61K 31/4439
A61P 31/04
A61P 31/06

US Classification:

514338, 514333, 514256, 544335, 5462744, 546256

Abstract:

The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

US Patent:

8067606, Nov 29, 2011

Filed:

Jun 12, 2009

Appl. No.:

12/483312

Inventors:

Paul Charifson - Framingham MA, US
David Deininger - Waltham MA, US
Anne-Laure Grillot - Somerville MA, US
Yusheng Liao - Lexington MA, US
Steven Ronkin - Watertown MA, US
Dean Stamos - Carlsbad CA, US
Emanuele Perola - Brookline MA, US
Tiansheng Wang - Concord MA, US
Arnaud LeTiran - Lexington MA, US
Joseph Drumm - Westborough MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 401/14
A61K 31/444
A61K 31/4439

US Classification:

546256, 544333, 5462734, 514333, 514256

Abstract:

The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.

US Patent:

8188095, May 29, 2012

Filed:

Oct 7, 2008

Appl. No.:

12/246778

Inventors:

Paul Charifson - Framingham MA, US
David Deininger - Waltham MA, US
Anne-Laure Grillot - Somerville MA, US
Yusheng Liao - Lexington MA, US
Steven Ronkin - Watertown MA, US
Dean Stamos - Carlsbad CA, US
Emanuele Perola - Brookline MA, US
Tiansheng Wang - Concord MA, US
Arnaud Le Tiran - Lexington MA, US
Joseph Drumm - Westborough MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/44
C07D 401/04
C07D 401/14

US Classification:

514256, 514269, 514318, 514338, 514394, 544 81, 544124, 544242, 548221, 5483061

Abstract:

The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.