Dr. Francisco works in Youngstown, OH and specializes in Podiatric Medicine. Dr. Francisco is affiliated with Salem Regional Medical Center, St Elizabeth Health Center and Valleycare Northside Medical Center.
Clay B. Siegall - Edmonds WA, US Alan F. Wahl - Mercer Island WA, US Joseph A. Francisco - Edmonds WA, US
Assignee:
Seattle Genetics, Inc. - Bothell WA
International Classification:
C07H 2104 C12N 119 C12N 121 C12N 516 C12N 1500
US Classification:
435 696, 435328, 435334, 4353431, 536 2353
Abstract:
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
Methods For The Treatment And Prevention Of Cancer Using Anti-Cd40 Antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
Joseph A. Francisco - Edmonds WA, US Grant Risdon - Clayton MO, US Alan F. Wahl - Mercer Island WA, US Clay Siegall - Edmonds WA, US
Assignee:
Seattle Genetics, Inc. - Bothell WA
International Classification:
A61K 39/395
US Classification:
4241381, 4241411, 4241551, 4241341, 4241331
Abstract:
The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's Disease cells. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.
Methods For Treating Immune Disorders Or Cancer With Anti-Cd40 Antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
Methods For The Treatment Of Cancer Using Anti-Cd40 Antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
Methods For Augmenting An Immune Response Using Anti-Cd40 Antibodies
The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
Joseph Francisco - Edmonds WA, US Grant Risdon - Seattle WA, US Alan Wahl - Mercer Island WA, US Clay Siegall - Edmonds WA, US Peter Senter - Seattle WA, US Sveltana Doronina - Snohomish WA, US Brian Toki - Lynnwood WA, US
International Classification:
A61K039/395 C07K016/30
US Classification:
424/144100, 530/388220
Abstract:
The present invention relates to methods and compositions for the treatment of Hodgkin's Disease, comprising administering proteins characterized by their ability to bind to CD30, or compete with monoclonal antibodies AC10 or HeFi-1 for binding to CD30, and exert a cytostatic or cytotoxic effect on Hodgkin's disease cells in the absence of effector cells or complement. Such proteins include derivatives of monoclonal antibodies AC10 and HeFi-1. The proteins of the invention can be human, humanized, or chimeric antibodies; further, they can be conjugated to cytotoxic agents such as chemotherapeutic drugs. The invention further relates to nucleic acids encoding the proteins of the invention. The invention yet further relates to a method for identifying an anti-CD30 antibody useful for the treatment or prevention of Hodgkin's Disease.
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