Joseph Edward Gabriels

US Patent:

6642005, Nov 4, 2003

Filed:

Aug 30, 2002

Appl. No.:

10/233225

Inventors:

Jack T. Leonard - South Hamilton MA
Constance MacDonald - Stoneham MA
Joseph Gabriels - Arlington MA

Assignee:

Millipore Corporation - Bedford MA

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 536 231, 210650

Abstract:

A method for sequencing reaction cleanup adapted to remove contaminants from a sequencing reaction, comprising the steps of: providing a defined quantity of sequencing reaction product; providing at least one ultrafiltration membrane having at least one surface; transferring the suspended sequencing reaction product to the surface of the ultrafiltration membrane; and applying a first constant pressure differential to the ultrafiltration membrane at a force capable of producing the sequencing reaction product substantially free of the contaminants.

US Patent:

6645722, Nov 11, 2003

Filed:

Oct 19, 2001

Appl. No.:

10/040037

Inventors:

Jack T. Leonard - South Hamilton MA
Constance MacDonald - Stoneham MA
Joseph Gabriels - Arlington MA

Assignee:

Millipore Corporation - Bedford MA

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 536 231, 210650

Abstract:

A method for sequencing reaction cleanup adapted to remove contaminants from a sequencing reaction, comprising the steps of: providing a defined quantity of sequencing reaction product; providing at least one ultrafiltration membrane having at least one surface; transferring the suspended sequencing reaction product to the surface of the ultrafiltration membrane; and applying a first constant pressure differential to the ultrafiltration membrane at a force capable of producing the sequencing reaction product substantially free of the contaminants.

US Patent:

6893562, May 17, 2005

Filed:

May 5, 2000

Appl. No.:

09/565963

Inventors:

Jeffrey S. Busnach - Billerica MA, US
Brian Foley - Westford MA, US
Phillip Clark - Wakefield MA, US
Joseph E. Gabriels - Arlington MA, US

Assignee:

Millipore Corporation - Bedford MA

International Classification:

B01D029/92

US Classification:

210248, 210406, 210473, 210474, 2104161, 210919, 422101

Abstract:

A device and method for removal of liquid from the downstream side of a membrane or a well, such as a well of a multiwell plate. More specifically, the present invention is directed to a wicking structure, which channels droplets of liquid away from a membrane in communication with a plurality of wells. In the preferred embodiment, the wicking structure is placed in a manifold.

US Patent:

6989099, Jan 24, 2006

Filed:

Feb 18, 2005

Appl. No.:

11/061202

Inventors:

Jeffrey S. Busnach - Billerica MA, US
Brian Foley - Westford MA, US
Phillip Clark - Wakefield MA, US
Joseph E. Gabriels - Arlington MA, US

Assignee:

Millipore Corporation - Billerica MA

International Classification:

B01D 29/92

US Classification:

210650, 210808, 210248, 210406, 210474, 210919, 422101

Abstract:

A device and method for removal of liquid from the downstream side of a membrane or a well, such as a well of a multiwell plate. More specifically, the present invention is directed to a wicking structure, which channels droplets of liquid away from a membrane in communication with a plurality of wells. In the preferred embodiment, the wicking structure is placed in a manifold.

US Patent:

7112281, Sep 26, 2006

Filed:

Nov 29, 2005

Appl. No.:

11/289082

Inventors:

Jeffrey S. Busnach - Billerica MA, US
Brian Foley - Westford MA, US
Phillip Clark - Wakefield MA, US
Joseph E. Gabriels - Arlington MA, US

Assignee:

Millipore Corporation - Billerica MA

International Classification:

B01D 29/92

US Classification:

210650, 210808, 210248, 210406, 210474, 210919, 422101

Abstract:

A device and method for removal of liquid from the downstream side of a membrane or a well, such as a well of a multiwell plate. More specifically, the present invention is directed to a wicking structure, which channels droplets of liquid away from a membrane in communication with a plurality of wells. In the preferred embodiment, the wicking structure is placed in a manifold.

US Patent:

20030036086, Feb 20, 2003

Filed:

Aug 15, 2002

Appl. No.:

10/219401

Inventors:

Jack Leonard - South Hamilton MA, US
Joseph Gabriels - Arlington MA, US
Masaharu Mabuchi - Beverly MA, US
Gary LaBombard - Concord NH, US

International Classification:

C12Q001/68
B25B001/20
C12M001/34

US Classification:

435/006000, 435/287200, 269/045000

Abstract:

A system for holding a multiple welled plate during processing comprised of a multiple welled plate, typically containing 96, 384 or more individual wells, each having an open bottom closed by a membrane and a holder for such a plate. The holder is formed with a filter support portion that supports the lower surface of the filter during processing. The holder may optionally be thermally conductive or if not thermally conductive, may include an additional thermally conductive layer between the lowermost surface of the filter and the filter support portion to provide for thermal cycling applications.

US Patent:

49961543, Feb 26, 1991

Filed:

May 4, 1989

Appl. No.:

7/347448

Inventors:

Joseph E. Gabriels - Brighton MA

Assignee:

Millipore Corporation - Bedford MA

International Classification:

C12N 506
C12N 508

US Classification:

435240241

Abstract:

A method is described for producing tissue from cells, such as keratinocyte, epithelial or endothelial cells, in virto. Cells are grown on a porous cell-growth substrate having specific growth factors therein e. g. , on a collagen activated coated microporous substrate. Cells can be grown to form a confluent monolayer or differentiated tissue which can be used for studying cell toxicology.

US Patent:

51750929, Dec 29, 1992

Filed:

Feb 1, 1991

Appl. No.:

7/649648

Inventors:

Joseph E. Gabriels - Brighton MA

Assignee:

Millipore Corporation - Bedford MA

International Classification:

C12Q 102

US Classification:

435 29

Abstract:

A method is described for producing tissue from cells, such as keratinocyte, epithelial or endothelial cells, in vitro. Cells are grown on a porous cell-growth substrate having specific growth factors therein. Cells can be grown to form a confluent monolayer or differentiaed tissue which can be used for studying cell toxicology.