Thomas A. Steitz - Branford CT, US Peter B. Moore - North Haven CT, US Joseph A. Ippolito - Guilford CT, US Nenad Ban - Zurich, CH Poul Nissen - Aarhus, DE Jeffrey L. Hansen - Charleston SC, US
Assignee:
Yale University - New Haven CT Rib-X Pharmaceuticals, Inc. - New Haven CT
International Classification:
G01N033/48 G06F031/00 G06F017/00
US Classification:
702 19, 702 20, 702 27
Abstract:
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
Modulators Of Ribosomal Function And Identification Thereof
Thomas A. Steitz - Branford CT, US Peter B. Moore - North Haven CT, US Nenad Ban - Zürich, CH Poul Nissen - Aarhus N, DK Jeffrey Hansen - New Haven CT, US Joseph A. Ippolito - Guilford CT, US
Assignee:
Yale University - New Haven CT
International Classification:
G01N033/48 G06F031/00 G06F017/00 C12Q001/68
US Classification:
702 19, 702 20, 702 27, 435 6
Abstract:
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
Bifunctional Heterocyclic Compounds And Methods Of Making And Using Same
Deping Wang - West Haven CT, US Joyce A. Sutcliffe - Branford CT, US Adegboyega K. Oyelere - Hamden CT, US Timothy S. McConnell - Cheshire CT, US Joseph A. Ippolito - Guilford CT, US John N. Abelson - Pasadena CA, US Dane M. Springer - Yardley PA, US Joseph M. Salvino - Branford CT, US Rongliang Lou - Hamden CT, US Joel A. Goldberg - Milford CT, US Jay J. Farmer - New Haven CT, US Erin M. Duffy - Deep River CT, US Ashoke Bhattacharjee - West Haven CT, US
The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents, and/or prokinetic (gastrointestinal modulatory) agents, having the formula:.
Bifunctional Heterocyclic Compounds And Methods Of Making And Using Same
Deping Wang - West Haven CT, US Joyce A. Sutcliffe - Brandford CT, US Adegboyega K. Oyelere - Hamden CT, US Timothy S. McConnell - Cheshire CT, US Joseph A. Ippolito - Guilford CT, US John N. Abelson - Pasadena CA, US Dane M. Springer - Yardley PA, US Joseph M. Salvino - Branford CT, US Rongliang Lou - Cheshire CT, US Joel A. Goldberg - Milford CT, US Jay J. Farmer - New Haven CT, US Erin M. Duffy - Deep River CT, US Ashoke Bhattacharjee - West Haven CT, US
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
Ribosome Structure And Protein Synthesis Inhibitors
Thomas A. Steitz - Branford CT, US Peter B. Moore - North Haven CT, US Joyce A. Sutcliffe - Clinton CT, US Adegboyega K. Oyelere - New Haven CT, US Joseph A. Ippolito - Guilford CT, US
Assignee:
Rib-X Pharmaceuticals, Inc. - New Haven CT Yale University - New Haven CT
International Classification:
A61K 38/00
US Classification:
514 44
Abstract:
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
Ribosome Structure And Protein Synthesis Inhibitors
Thomas A. Steitz - Branford CT, US Peter B. Moore - North Haven CT, US Joyce A. Sutcliffe - Clinton CT, US Adegboyega K. Oyelere - New Haven CT, US Joseph A. Ippolito - Guilford CT, US
Assignee:
Rib-X Pharmaceuticals, Inc. - New Haven CT Yale University - New Haven CT
International Classification:
C07H 21/04 C12N 15/11
US Classification:
536 232, 514 44
Abstract:
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
Bifunctional Heterocyclic Compounds And Methods Of Making And Using Same
Deping Wang - West Haven CT, US Joyce Sutcliffe - Bradford CT, US Adegboyega Oyelere - Hamden CT, US Timothy McConnell - Cheshire CT, US Joseph Ippolito - Guilford CT, US John Abelson - Pasadena CA, US Dane Springer - Yardley PA, US Joseph Salvino - Branford CT, US Joel Goldberg - Milford CT, US Rongliang Lou - Cheshire CT, US Jay Farmer - New Haven CT, US Erin Duffy - Deep River CT, US Ashoke Bhattacharjee - West Haven CT, US
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
Ribosome Structure And Protein Synthesis Inhibitors
Thomas A. Steitz - Branford CT, US Peter B. Moore - North Haven CT, US Nenad Ban - Zurich, CH Poul Nissen - Aarhus N, DK Jeffrey Hansen - New Haven CT, US Joseph A. Ippolito - Guilford CT, US
International Classification:
G06F 17/50
US Classification:
703 1
Abstract:
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.