Joseph Daniel Kowalski

US Patent:

20200368431, Nov 26, 2020

Filed:

Aug 13, 2020

Appl. No.:

16/992772

Inventors:

- Portland OR, US
Robert S. CARGILL - Portland OR, US
Gabriel HEINRICH - Portland OR, US
Sheila BENWARE - Clackamas OR, US
Mark VREEKE - Aliso Viejo CA, US
Joseph D. KOWALSKI - Portland OR, US
Thomas SEIDL - Tigard OR, US

International Classification:

A61M 5/172
A61B 5/145
A61B 5/1473
A61M 5/158
A61M 5/165
A61M 5/142

Abstract:

This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing. Another is to use a size exclusion filter located in line with the insulin delivery tubing in order to remove the smaller phenolic preservative molecules while allowing the larger insulin molecules to pass unimpeded. These filtration concepts can also be more broadly applied, that is, the general concept of removal of unwanted drug formulation excipients from a drug delivery system.

US Patent:

20200240398, Jul 30, 2020

Filed:

Sep 16, 2019

Appl. No.:

16/572304

Inventors:

- BEAVERTON OR, US
Joseph Kowalski - Beaverton OR, US
Jereme Shaver - Beaverton OR, US

Assignee:

E BEAM INC. - BEAVERTON OR

International Classification:

F03H 1/00
H05H 1/48

Abstract:

Plasma cathodes for micro Hall and ion thrusters of unprecedented power efficiency, low cost, compactness, are provided. The cathodes employ, for example, a very small planar scandate cathode as electron source, delivering over 350 ma of discharge from an emitter area as small as only 0.012 cm2.

US Patent:

20160354542, Dec 8, 2016

Filed:

May 31, 2016

Appl. No.:

15/169432

Inventors:

William Kenneth Ward - Portland OR, US
Robert S. Cargill - Portland OR, US
Gabriel Heinrich - Portland OR, US
Sheila Benware - Clackamas OR, US
Mark Vreeke - Aliso Viejo CA, US
Joseph D. Kowalski - Portland OR, US
Thomas Seidl - Tigard OR, US

Assignee:

Pacific Diabetes Technologies - Portland OR

International Classification:

A61M 5/172
A61B 5/145
A61M 5/142
A61M 5/158
A61M 5/165
A61B 5/00
A61L 29/16
A61B 5/1473

Abstract:

This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing. Another is to use a size exclusion filter located in line with the insulin delivery tubing in order to remove the smaller phenolic preservative molecules while allowing the larger insulin molecules to pass unimpeded. These filtration concepts can also be more broadly applied, that is, the general concept of removal of unwanted drug formulation excipients from a drug delivery system.

US Patent:

20160228678, Aug 11, 2016

Filed:

Dec 31, 2015

Appl. No.:

14/986469

Inventors:

Robert S. Cargill - Portland OR, US
William Kenneth Ward - Portland OR, US
Joseph D. Kowalski - Portland OR, US

Assignee:

Pacific Diabetes Technologies - Portland OR

International Classification:

A61M 25/00
A61B 5/1486
A61B 5/145
A61M 5/14
A61B 5/00

Abstract:

This invention pertains to the concept of creating a strip that contains one or more amperometric biosensing electrodes and integrating this strip into the outer wall of a hollow catheter (cannula). The electrodes can be used for continuous sensing of an analyte such as glucose and the hollow lumen can be used concurrently for delivery of a drug such as insulin. There is a risk for electrode films to break apart during impact. However, if there is a metallic foil beneath (underlying) the thin film metal electrodes, durability and fatigue resistance are markedly improved. The term “foil” indicates a metal layer that is 2-15 μm in thickness. Foils can be created by rolling, hammering, electroplating, printing, or vacuum-deposition. A foil-polymer laminate is suitable as a substrate because it permits low-cost patterning and assembly into a durable, fatigue-resistant sensor.