- La Jolla CA, US Simone Moraes Mantovani - San Diego CA, US Russell S. Komor - San Diego CA, US Matthew Carey LaFave - Escondido CA, US Krishna Kannan - San Diego CA, US Joseph W. LaMattina - San Diego CA, US Joseph S. Lucas - San Diego CA, US Eric R. Moellering - San Diego CA, US
Disclosed herein are novel polypeptides having nuclease activity. The Mmc3 polypeptides function as Class 2 Type V effectors, and catalyze double stranded breaks in nucleic acid strands. The polypeptides are useful, for example, for gene editing systems such as CRISPR, to make site specific alterations of target nucleic acid sequences.