Joseph R Madsen

US Patent:

6383160, May 7, 2002

Filed:

Apr 29, 1999

Appl. No.:

09/301997

Inventors:

Joseph R. Madsen - Newton MA

Assignee:

Childrens Medical Center Corporation - Boston MA

International Classification:

A61M 500

US Classification:

604 10, 60416703

Abstract:

Variable anti-siphon devices are disclosed for use in cerebrospinal fluid shunt systems. Such devices can include a housing with an internal chamber, an adjustable barrier separating the chamber into two cavities, and a diaphragm that seats itself against the adjustable barrier with a seating force that is proportional to the pressure differential across it. The adjustable barrier advantageously allows the level of anti-siphon protection to be modified. In one embodiment, the height of the adjustable barrier may be varied. In another embodiment, the barrier is moved longitudinally within the internal chamber to vary the volume of each chamber.

US Patent:

6547734, Apr 15, 2003

Filed:

Oct 30, 2001

Appl. No.:

10/012774

Inventors:

Joseph R. Madsen - Newton MA
George A. Taylor - Wellesley MA

Assignee:

Childrens Medical Center Corporation - Boston MA

International Classification:

A61B 800

US Classification:

600438

Abstract:

Apparatus and methods are disclosed for non-invasive measurement of blood velocity in otherwise inaccessible body regions, and for correlating such measurements with externally applied pressure to detect and/or assess diseases or physiological abnormalities. The blood velocity measurements can be based on the Doppler shift that occurs when an ultrasonic wave is scattered by moving particles within the blood. Since blood vessels have elastic walls, the geometry of the walls, and therefore the flow dynamics, will change in response to elevated in vivo pressure. The change in resistance to blood flow resulting from these pressure induced changes to the blood vessel wall geometry can provide a measure of intracranial pressure, ophthalmic pressure or various other body conditions that affect blood perfusion. Since the blood vessel wall geometry changes rapidly in response to such changes in pressure, the invention can be used to detect hydrocephalus, retinopathy, papilledema and other physiological abnormalities manifested by pressure changes.

US Patent:

6761718, Jul 13, 2004

Filed:

Sep 6, 2001

Appl. No.:

09/947707

Inventors:

Joseph R. Madsen - Newton MA

Assignee:

Childrens Medical Center Corp. - Boston MA

International Classification:

A61B 1818

US Classification:

606 50

Abstract:

The present invention provides a bipolar coagulator which can be passed through the internal lumen of a ventricular catheter previously implanted into a cranial ventricle of a living subject and engaged in-situ. The bipolar coagulator will provide bipolar electrical arc currents for coagulation cauterization of adherent brain tissues, such as the choroid plexus, which occludes fluid flow into the intake drainage holes in the implanted ventricular catheter and often becomes adherent to the catheter in-situ. The cautery current provided by the bipolar coagulator is direction oriented and spatially controlled; thereby providing a better distribution of electrical current and heat within the surrounding cranial tissues; and thereby avoiding major complications of damage to intracranial structures such as blood vessels as well as avoiding the severe subarachnoid hemorrhages which are typical using other kinds of coagulation instruments.

US Patent:

7225554, Jun 5, 2007

Filed:

Feb 28, 2005

Appl. No.:

11/069805

Inventors:

Joseph R. Madsen - Newton MA, US

Assignee:

Children's Hospital Boston - Boston MA

International Classification:

A61B 5/103
G01B 5/20

US Classification:

33512, 33552, 600587

Abstract:

The invention relates to apparatus and methods for measuring a human head. The apparatus disclosed herein involve the use of linear rulers, or rotating contacting members, coupled to a support member. The apparatus disclosed herein can be positioned on a human head, using the methods disclosed herein, to determine the outer contour of the head. Such a measurement can aid in the diagnosis and monitoring of various abnormalities of the human head, including plagiocephaly.

US Patent:

7618391, Nov 17, 2009

Filed:

Apr 20, 2005

Appl. No.:

11/109987

Inventors:

Joseph R. Madsen - Newton MA, US
Dentcho Ivanov - West Orange NJ, US

Assignee:

Children's Medical Center Corporation - Boston MA
New Jersey Institute of Technology - Newark NJ

International Classification:

A61M 5/00
H02N 2/00
H01L 41/00
F15B 13/04
F16K 31/02

US Classification:

604 9, 604540, 310317, 310330, 310345, 310364, 137596, 13762517, 13732533, 137 84, 25112902, 25112906

Abstract:

Microfluidic shunt valves are disclosed having a deflectable element capable of being held in a closed position to occlude the passage of fluid between an inlet and outlet and, when not held in the closed position, the deflectable element is adapted to oscillate in response to fluid pressure pulses and thereby facilitate fluid passage through the valve. Controls for activating the deflectable element to permit fluid passage are also included.

US Patent:

20060042013, Mar 2, 2006

Filed:

Aug 31, 2004

Appl. No.:

10/930196

Inventors:

Joseph Madsen - Newton MA, US

Assignee:

Children's Hospital Boston - Boston MA

International Classification:

A47G 9/00

US Classification:

005637000, 005640000, 005733000, 005655000

Abstract:

The present invention relates to a head support device for the treating and prevention of plagiocephaly in infants. The device removes pressure from a desired area of an infant's head.

US Patent:

20060075648, Apr 13, 2006

Filed:

Sep 23, 2005

Appl. No.:

11/234355

Inventors:

Joseph Madsen - Newton MA, US
James Goldie - Lexington MA, US
Kristen Choppy - Somerville MA, US
Thieu Truong - North Easton MA, US

International Classification:

G01B 3/34
G01B 5/02
A61B 5/107

US Classification:

033512000, 600587000

Abstract:

The invention relates to apparatus and methods for measuring a human head. The apparatus disclosed herein involve the use of linear rulers, or rotating contacting members, coupled to a support member. The apparatus disclosed herein can be positioned on a human head, using the methods disclosed herein, to determine the outer contour of the head. Such a measurement can aid in the diagnosis and monitoring of various abnormalities of the human head, including plagiocephaly.

US Patent:

60865334, Jul 11, 2000

Filed:

Jun 12, 1998

Appl. No.:

9/097067

Inventors:

Joseph R. Madsen - Newton MA
George A. Taylor - Wellesley MA

Assignee:

Children's Medical Center Corporation - Boston MA

International Classification:

A61B 800

US Classification:

600438

Abstract:

Apparatus and methods are disclosed for non-invasive measurement of blood velocity in otherwise inaccessible body regions, and for correlating such measurements with externally applied pressure to detect and/or assess diseases or physiological abnormalities. The blood velocity measurements can be based on the Doppler shift that occurs when an ultrasonic wave is scattered by moving particles within the blood. Since blood vessels have elastic walls, the geometry of the walls, and therefore the flow dynamics, will change in response to elevated in vivo pressure. The change in resistance to blood flow resulting from these pressure induced changes to the blood vessel wall geometry can provide a measure of intracranial pressure, ophthalmic pressure or various other body conditions that affect blood perfusion. Since the blood vessel wall geometry changes rapidly in response to such changes in pressure, the invention can be used to detect hydrocephalus, retinopathy, papilledema and other physiological abnormalities manifested by pressure changes.