Joseph G Marcus

US Patent:

20210166813, Jun 3, 2021

Filed:

Nov 25, 2020

Appl. No.:

17/105175

Inventors:

- Menlo Park CA, US
Alex Aravanis - San Mateo CA, US
Angela Lai - Los Altos Hills CA, US
Oliver Claude Venn - San Francisco CA, US
Richard Rava - Redwood City CA, US
Jing Xiang - San Carlos CA, US
Joseph Marcus - Venice CA, US

International Classification:

G16H 50/20
G16B 20/00
G16B 5/00
G16B 40/30
G16H 50/70
G16H 50/30

Abstract:

Systems and methods are provided for determining whether a test subject has a disease condition. In one aspect, the method includes determining at least first and second genotypic data constructs for a test subject, formed from data collected from first and second sample from the subject, respectively, at different times. The first and second genotypic data constructs are inputted into a model for the disease condition, thereby generating first and second model score sets for the disease condition, respectively. A test delta score set is determined based on a difference between the first and second model score sets. The test delta score set is evaluated against a plurality of reference delta score sets, to determine the disease condition of the test subject, where each reference delta score set is for a respective reference subject in a plurality of reference subjects.