Joseph C Matteo

US Patent:

6599484, Jul 29, 2003

Filed:

May 12, 2000

Appl. No.:

09/569780

Inventors:

Steven S. Zigler - Knoxville TN
Thomas Mangner - Chelsea MI
Joseph C. Matteo - Knoxville TN

Assignee:

CTI, Inc. - Knoxville TN

International Classification:

B01J 1900

US Classification:

422130, 422 99, 422102, 422129, 422138

Abstract:

An apparatus for processing radionuclides which generally includes a reaction vessel and a block. The reaction vessel includes a test tube and a cover secured to a top portion of the test tube. The cover defines at least one opening for receiving an input tube therethrough such that raw materials, reagents, gases and products can be introduced into or removed from the test tube. The block defines a vessel receptacle, an upper temperature changing means and a lower temperature changing means. The vessel receptacle defines an upper zone and a lower zone and is configured to receive the reaction vessel therein in a manner such that an upper zone space is defined between an exterior of the reaction vessel and an inner wall of the vessel receptacle in the upper zone. Likewise, a lower zone space is defined between an exterior of the reaction vessel and inner wall of the vessel receptacle in the lower zone. The upper temperature changing means serves to alter the temperature of gas in the upper zone space and the lower temperature changing means serve to alter the temperature of gas in said lower zone space.

US Patent:

7641860, Jan 5, 2010

Filed:

Jun 1, 2006

Appl. No.:

11/421678

Inventors:

Joseph C. Matteo - Walland TN, US

Assignee:

NanoTek, LLC - Louisville TN

International Classification:

B01J 10/00
B01L 9/00
C12M 1/00

US Classification:

422100, 422104, 422129, 4352891

Abstract:

A modular and reconfigurable multi-stage microreactor cartridge apparatus provides a manifold for removably attaching multiple microfluidic components such as microreactors. The microfluidic components are attached at microfluidic component ports having two input/output terminals, which microfluidic component ports are connected via connections internal to the manifold to other microfluidic component ports providing a microfluidic circuit. The microfluidic component may be a microfluidic circuit plug-in or a cartridge having a mounting block with two input/output terminals and a fastener aperture and fluidic tubing having a first and second transport portion and a body portion, the three portions being disposed in substantially parallel planes and the body portion being would in a coil around a spool. The coil is connected to the mounting block by either epoxy protector or L-bracket. The cartridge has a first and a second remote input/output terminal connected to the first and second transport lines respectively.

US Patent:

7718436, May 18, 2010

Filed:

Apr 23, 2003

Appl. No.:

10/421324

Inventors:

Steven S. Zigler - Knoxville TN, US
Joseph C. Matteo - Knoxville TN, US
Thomas Mangner - Chelsea MI, US

Assignee:

Siemens Medical Solutions USA, Inc. - Malvern PA

International Classification:

G01N 23/00

US Classification:

436 57, 436179, 436180, 422 99, 422101, 422102, 376194, 376195

Abstract:

A method of producing multiple batches of a radiopharmaceutical, such as FDG. The method includes the steps of transferring the appropriate liquids to a production apparatus, processing the liquids to produce the radiopharmaceutical, delivering the radiopharmaceutical to a container, automatically cleaning the apparatus, and repeating the previous steps, as desired. The apparatus for multi-batch production of FDG includes a reagent delivery system, a reaction vessel, a filter assembly, and a control system. The combination of these components provides a method that is capable of producing multiple batches of a radiopharmaceutical with minimal operator intervention and, consequently, minimal radiation exposure.

US Patent:

7790124, Sep 7, 2010

Filed:

Dec 7, 2009

Appl. No.:

12/632027

Inventors:

Joseph C. Matteo - Walland TN, US

Assignee:

NanoTek, LLC - Walland TN

International Classification:

B01J 14/00

US Classification:

422240, 422100, 422104, 422129

Abstract:

A modular and reconfigurable multi-stage microreactor cartridge apparatus provides a manifold for removably attaching multiple microfluidic components such as microreactors. The microfluidic components are attached at microfluidic component ports having two input/output terminals, which microfluidic component ports are connected via connections internal to the manifold to other microfluidic component ports providing a microfluidic circuit. The microfluidic component may be a microfluidic circuit plug-in or a cartridge having a mounting block with two input/output terminals and a fastener aperture and fluidic tubing having a first and second transport portion and a body portion, the three portions being disposed in substantially parallel planes and the body portion being would in a coil around a spool. The coil is connected to the mounting block by either epoxy protector or L-bracket. The cartridge has a first and a second remote input/output terminal connected to the first and second transport lines respectively.

US Patent:

7854902, Dec 21, 2010

Filed:

Aug 22, 2007

Appl. No.:

11/843458

Inventors:

Joseph C. Matteo - Louisville TN, US

Assignee:

NanoTek, LLC - Walland TN

International Classification:

B01J 10/00

US Classification:

422129, 422159, 422240

Abstract:

A microfluidic reactor cartridge having glass capillary tubing wound in a coil and surrounded by a ceramic housing capable use in high temperatures and method for using same. In another embodiment, the microfluidic cartridge is a serpentine reactor cartridge with a serpentine microreactor channel formed in a ceramic housing. The serpentine reactor cartridge has an inlet tube attached to its inlet port and an outlet tube attached to its outlet port. The inlet port is a macro/micro interface and the outlet port is a micro/macro interface useful in gas phase reactions where solids must be used to produce a reactant. The method for using a microfluidic reactor cartridge includes two phases, the first phase for producing a radioactive labeled gas such as methyl iodide and the second phase is a methylation reaction.

US Patent:

7998418, Aug 16, 2011

Filed:

May 29, 2007

Appl. No.:

11/754623

Inventors:

Joseph C. Matteo - Walland TN, US

Assignee:

NanoTek, LLC - Walland TN

International Classification:

B01L 99/10
G01N 15/06
G01N 33/00
G01N 33/48

US Classification:

422101, 422100, 422102, 422103, 422 681, 436 43, 436174, 436177, 436180, 436181

Abstract:

An evaporator and concentrator in a reactor and loading system concentrates ions such as fluoride ions in some embodiments, and evaporates micro- to milliliter volumes of liquid solutions including intermediate and final product in other embodiments. It efficiently re-dissolves the evaporated solution generating a product, which is transferred to an external system as desired. The external system may be a micro-fluidic reactor system and/or loading system. The evaporator/concentrator has an input port for introducing liquids and solids. A capillary tube introduces gas, such as nitrogen gas, into a volume of solution contained within a v-vial, which produces an evaporating micro bubbler. A concentric tube, surrounding the capillary tube in some embodiments, introduces gas into the empty volume above the solution inside the v-vial, which is referred to as a vapor sweep. The vapor sweep assists in removing the evaporated solution from the v-vial through a vacuum tube.

US Patent:

20040258615, Dec 23, 2004

Filed:

Apr 20, 2004

Appl. No.:

10/827991

Inventors:

Charles Buchanan - Knoxville TN, US
Henry Padgett - Hermosa Beach CA, US
Thomas Collier - Paramus NJ, US
Joseph Matteo - Walland TN, US
Charles Alvord - Farragut TN, US

Assignee:

Molecular Technologies, Inc. - Culver City CA

International Classification:

A61K051/00

US Classification:

424/001110

Abstract:

The invention provides a method and apparatus for preparation of radiochemicals wherein the reaction that couples the radioactive isotope to the reactive precursor to form a positron-emitting molecular imaging probe is performed in a microfluidic environment. The method comprises providing a micro reactor, providing a precursor solution and introducing the precursor solution into the micro reactor, wherein the precursor solution comprises a reactive precursor adapted for reaction with a radioactive isotope and dissolved in an organic solvent, providing a radioactive solution and introducing the radioactive solution into the micro reactor, wherein the radioactive solution comprises a radioactive isotope dissolved in an organic solvent, and uniting the precursor solution with the radioactive solution in a microchannel of the micro reactor enabling the reactive precursor to react with the radioactive isotope as the precursor solution and radioactive solution flow in the microchannel to form a radiochemical in solution.

US Patent:

20040262158, Dec 30, 2004

Filed:

Apr 21, 2004

Appl. No.:

10/828844

Inventors:

Charles Alvord - Farragut TN, US
Charles Buchanan - Knoxville TN, US
Joseph Matteo - Walland TN, US
Henry Padgett - Hermosa Beach CA, US
Thomas Collier - Paramus NJ, US

Assignee:

Molecular Technologies, Inc. - Culver City CA

International Classification:

G01N027/26
G01N027/27

US Classification:

204/400000

Abstract:

A beta detector assembly for use in the synthesis and analysis of radiopharmaceuticals, such as in microfluidic radiochromatography. The beta detector assembly includes a base, preferably fabricated from glass so as to take advantage of electroosmotic flow, that serves as the body of the beta detector assembly. A microfluidic channel passes through the length of the base. A solid-state charge particle detector, for detecting beta particles, is provided and is positioned with respect to the base so as to receive beta particles. A portion of the base is disposed between the microfluidic channel and the solid-state charge particle detector and has a thickness that is selected to substantially allow transmission of beta particles there thru for detection by the charge particle detector. In one embodiment, the base is fabricated of glass. In another embodiment, the base is fabricated of silicon such that the base and the solid-state charge particle detector are integral.