Joseph H Metzger

US Patent:

20050257279, Nov 17, 2005

Filed:

Jun 27, 2003

Appl. No.:

10/518955

Inventors:

Su Qian - Princeton NJ, US
Leonardus Van der Ploeg - Scotch Plains NJ, US
Howard Chen - Westfield NJ, US
Drew Weingarth - East Brunswick NJ, US
Myrna Trumbauer - Yardley PA, US
Joseph Metzger - Fanwood NJ, US

International Classification:

A01K067/027
C12N005/06

US Classification:

800018000, 435354000

Abstract:

Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding agouti-related protein (AgRP). AgRP deficient transgenic animals have a reduced day time respiratory quotient (RQ), indicating that AgRP is involved in the regulation of energy metabolism, resulting in the reduced usage of fat as an energy source. These AgRP deficient transgenic animals can be used to select for and test potential modulators of AgRP. This data allows for methods of screening for AgRP modulators which regulate energy metabolism and caloric utilization. The disclosure also relates to a NPY/AgRP double knockout mouse which can be used to select for and test potential modulators (e.g., agonists or antagonists) of AgRP and/or NPY.

US Patent:

39772489, Aug 31, 1976

Filed:

Apr 3, 1975

Appl. No.:

5/564668

Inventors:

Joseph H. Metzger - Warminster PA

Assignee:

Fischer & Porter Co. - Warminster PA

International Classification:

G01F 124

US Classification:

73209

Abstract:

A rotameter system adapted to produce an output indication that is linearly proportional to flow. The primary element of the system includes a float contained in a variable area tube through which flows the fluid to be measured, the float being raised or lowered in the tube as a function of flow rate, and a bar magnet mechanically coupled to the float and axially movable therewith. The secondary element of the system includes a rotatable follower magnet magnetically coupled to the bar magnet and a pointer mounted on the shaft of the follower magnet whereby the pointer sweeps from zero to maximum along a scale as the float travels from its low to its high position. A mass is eccentrically mounted on the shaft of the follower magnet, the position of the mass relative to the shaft axis being adjusted to produce a moment compensating for the non-linear relationship between flow rate and pointer movement.