Joseph Michael Monahan

US Patent:

52082601, May 4, 1993

Filed:

Mar 29, 1990

Appl. No.:

7/501640

Inventors:

Alex A. Cordi - St. Louis MO
Joseph B. Monahan - Black Jack MO
Robert M. Williams - Fort Collins CO

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A01N 3712
A01N 3744

US Classification:

514561

Abstract:

A class of vinyl glycine derivatives is described for use in memory and learning enhancement or for treatment of a cognitive disorder. The vinyl glycine derivatives of particular interest are compounds of Formula I wherein the double bond is in trans configuration, R. sup. 1 is lower alkyl, R. sup. 2 is hydrido, R. sup. 3 is amino and X is hydroxymethyl. ##STR1##.

US Patent:

51771098, Jan 5, 1993

Filed:

Jul 19, 1991

Appl. No.:

7/732881

Inventors:

Roberto Pellicciari - Perugia, IT
Benedetto Natalini - Perugia, IT
Maura Marinozzi - Fermo, IT
Alexis A. Cordi - St. Louis MO
Joseph B. Monahan - Black Jack MO
Thomas H. Lanthorn - Ballwin MO

Assignee:

G. D. Searle & Co. - Chicago IL

International Classification:

A61K 3119

US Classification:

514572

Abstract:

Compounds, compositions and methods are described for treating a CNS disorder such as a cognitive disorder, epilepsy, depression, Parkinson's disease, Alzheimer's disease, a neurodegenerative disease or neurotoxic injury. Compound of interest are 2-amino-4,5-methyleneadipic acid compounds and derivatives defined by the formula I: ##STR1## wherein R. sup. 1 is selected from hydrido, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, arylthioalkyl, ##STR2## with each of R. sup. 2, R. sup. 3, R. sup. 4 and R. sup. 5 being independently selected from hydrido, alkyl, cycloalkyl, aryl and aralkyl; wherein each of X and Y is independently selected from hydroxyl, alkoxy, alkylthio, amino and ##STR3## with each of R. sup. 6 and R. sup. 7 being independently selected from hydrido, alkyl, cycloalkyl, aryl and aralkyl; wherein any of R. sup. 1 through R. sup.