Joseph John Otto

US Patent:

20200400673, Dec 24, 2020

Filed:

Sep 2, 2020

Appl. No.:

17/010069

Inventors:

- Rockland MA, US
Joseph John Otto - Norfolk VA, US

Assignee:

Creatics LLC - Rockland MA

International Classification:

G01N 33/574
A61K 31/702
A61K 9/00
G01N 33/533

Abstract:

Described herein are non-invasive or minimally invasive methods and compositions for collecting and assessing samples for detection of gastrointestinal (GI) tract cancers and pancreatic cancers. Samples comprising gastrointestinal lavage fluid (GLF) are obtained from subjects and screened against a glycan microarray to reveal disease-specific glycan-binding patterns by immunoglobulins contained in the GLF, especially immunoglobulin A (IgA). The disease-specific glycan-binding patterns include a disease-specific glycan or subset of glycans from the microarray that are bound by the immunoglobulins in GLF at highest intensities or at lowest intensities, as well as one or more glycan motifs found within this disease-specific subset of glycans.