The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabilities, and/or cellular tropisms as compared with current AAV vectors.
Virus Vectors And Methods Of Making And Administering The Same
Joseph Rabinowitz - Carrboro NC, US Richard Samulski - Chapel Hill NC, US Weidong Xiao - Jenkintown PA, US
International Classification:
A61K 48/00 C12N 15/861 C12N 7/00
US Classification:
424093200, 435456000, 435235100
Abstract:
The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabilities, and/or cellular tropisms as compared with current AAV vectors.
Virus Vectors And Methods Of Making And Administering The Same
Joseph Rabinowitz - Carrboro NC, US Richard Samulski - Chapel Hill NC, US Weidong Xiao - Jenkintown PA, US
International Classification:
A61K 48/00 C12N 15/861 C12N 7/00
US Classification:
424093200, 435235100, 435456000
Abstract:
The present invention provides genetically-engineered capsids and viruses designed to introduce a heterologous gene into a target cell. The of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabilities, and/or cellular tropisms as compared with current AAV vectors.
Recombinant Parvovirus Vectors And Method Of Making
Joseph E. Rabinowitz - Carrboro NC Richard Jude Samulski - Chapel Hill NC Weidong Xiao - Jenkintown PA
Assignee:
The University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
A61B 5055
US Classification:
424 932, 424 931, 424 9321, 424 933, 424 936
Abstract:
The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabilities, and/or cellular tropisms as compared with current AAV vectors.
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"It's very icy, especially below Crater Rock," said Reach and Treat paramedic Joseph Rabinowitz, one of the rescuers. "This is the second fall we have responded to this weekend -- fortunately, the first climber was uninjured. Climbers should exercise extreme caution while descending."