Joseph W Thompson

US Patent:

7862829, Jan 4, 2011

Filed:

Jul 8, 2005

Appl. No.:

11/628512

Inventors:

Robert E. Johnston - Chapel Hill NC, US
Joseph M. Thompson - Chapel Hill NC, US

Assignee:

University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 45/00
A61K 35/76
A61K 39/193

US Classification:

4242811, 4242051, 4242181, 4241991, 424 932

Abstract:

The present invention provides viral adjuvants for enhancing an immune response to an immunogen. In particular embodiments, the viral adjuvant is an alphavirus adjuvant or a Venezuelan Equine Encephalitis viral adjuvant. Also provided are compositions comprising the viral adjuvant and an immunogen, and pharmaceutical formulations comprising the viral adjuvant or compositions of the invention in a pharmaceutically acceptable carrier. Further provided are methods of producing an immune response against an immunogen in a subject comprising administering the immunogen and a viral adjuvant of the invention to the subject.

US Patent:

7937303, May 3, 2011

Filed:

Sep 30, 2003

Appl. No.:

10/673431

Inventors:

Gerardo Kobeh - Bethesda MD, US
Frank Godeby - Bethesda MD, US
James Keith Harmon - Alexandria VA, US
Joseph Thompson - Vienna VA, US

Assignee:

SAP AG - Walldorf

International Classification:

G06Q 40/00

US Classification:

705 35

Abstract:

A system and method for managing grants received from one or more sponsors is proposed. The grants management system receives a transaction request and retrieves data associated with the transaction request from a data cube. The grants management system then determines, from the perspective of the sponsors, if the transaction request satisfies administrative and financial requirements imposed by the sponsors. If the administrative and financial requirements are satisfied, the transaction request is admitted.

US Patent:

20110064772, Mar 17, 2011

Filed:

Nov 24, 2010

Appl. No.:

12/954021

Inventors:

Robert E. Johnston - Chapel Hill NC, US
Joseph M. Thompson - Raleigh NC, US

International Classification:

A61K 39/39
C07H 21/02
C12N 5/0783
C12P 19/34
A61P 31/00

US Classification:

4242811, 536 2372, 435325, 435 911

Abstract:

The present invention provides viral adjuvants for enhancing an immune response to an immunogen. In particular embodiments, the viral adjuvant is an alphavirus adjuvant or a Venezuelan Equine Encephalitis viral adjuvant. Also provided are compositions comprising the viral adjuvant and an immunogen, and pharmaceutical formulations comprising the viral adjuvant or compositions of the invention in a pharmaceutically acceptable carrier. Further provided are methods of producing an immune response against an immunogen in a subject comprising administering the immunogen and a viral adjuvant of the invention to the subject.

US Patent:

20110070260, Mar 24, 2011

Filed:

Sep 3, 2010

Appl. No.:

12/875369

Inventors:

Ralph S. Baric - Haw River NC, US
Anna LoBue - South San Francisco CA, US
Robert Edward Johnston - Chapel Hill NC, US
Joseph Thompson - Gainesville FL, US
Lisa Lindesmith - Apex NC, US

International Classification:

A61K 39/125
A61P 37/04
A61P 31/14

US Classification:

4242021, 4242161

Abstract:

The invention provides immunogenic formulations comprising virus-like particles (VLPs) from two or more genoclusters and/or strains of norovirus in a pharmaceutically acceptable carrier. In representative embodiments, the formulation also comprises an adjuvant, for example, a viral adjuvant or CpG. The invention also provides methods of inducing an immune response to one or more noroviruses.

US Patent:

41667298, Sep 4, 1979

Filed:

Jul 26, 1977

Appl. No.:

5/819205

Inventors:

Joseph K. Thompson - Washington DC
Robert C. Clark - Annandale VA
George H. Fielding - Alexandria VA
Harold F. Bogardus - Copenhagen NY

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

B03C 308
B03C 312
B03C 360

US Classification:

55138

Abstract:

Collector plates for use in the second stage of a two-stage electrostatic ecipitator comprise plates having non-conducting surfaces to which a coating of low conductivity, typically between 300 and 150,000 ohms per square, is affixed. One embodiment of such plates typically comprises a rigid, non-conducting plastic material coated with a material of low conductivity. Another embodiment of the present invention comprises a metallic plate coated with an insulating material of high dielectric strength, typically with a dielectric constant of at least 3000, to which the above mentioned low-conductivity coating is affixed. The collector plates may be mounted in such a manner as to maintain the airflow through the second stage of the precipitator in a direction virtually parallel to the surface of the plates.