- Princeton NJ, US Joseph TOTH - Belmont MA, US Ginger C. RAKESTRAW - Somerville MA, US
International Classification:
C07K 16/28 A61P 29/00 A61P 37/00 C12N 15/63
Abstract:
Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
Glypican-3-Binding Fibronectin Based Scaffold Molecules
- Princeton NJ, US Joseph TOTH - Belmont MA, US Ginger C. RAKESTRAW - Somerville MA, US Irvith M. CARVAJAL - Somerville MA, US Steven R. O'NEIL - Wayland MA, US Guodong CHEN - East Brunswick NJ, US Richard Y. HUANG - Bridgewater NJ, US Bryan C. BARNHART - San Francisco CA, US John Thomas LOFFREDO - Yardley PA, US Christina TERRAGNI - Wilmington MA, US
International Classification:
C07K 14/78 A61K 47/64 A61K 47/60 G01N 33/68
Abstract:
Provided herein are polypeptides which include tenth fibronectin type III domains (Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 Fn3 drug conjugates are also provided.
Glypican-3-Binding Fibronectin Based Scaffold Molecules
- Princeton NJ, US Joseph TOTH - Belmont MA, US Ginger C. RAKESTRAW - Somerville MA, US Irvith M. CARVAJAL - Somerville MA, US Steven R. O'NEIL - Wayland MA, US Guodong CHEN - East Brunswick NJ, US Richard Y. HUANG - Bridgewater NJ, US Bryan C. BARNHART - San Francisco CA, US John Thomas LOFFREDO - Yardley PA, US Christina TERRAGNI - Wilmington MA, US
International Classification:
C07K 14/78 A61K 47/64 G01N 33/68
Abstract:
Provided herein are polypeptides which include tenth fibronectin type III domains (Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 Fn3 drug conjugates are also provided.