Joseph A Traina

US Patent:

8460745, Jun 11, 2013

Filed:

Sep 17, 2010

Appl. No.:

12/884503

Inventors:

James Mitchell - Windsor CA, US
Justin Peterson - Santa Rosa CA, US
Dishuan Chu - Rohnert Park CA, US
Joseph Traina - Napa CA, US
Salvador Avelar - Santa Rosa CA, US
Michele Silver - Windsor CA, US

Assignee:

Medtronic Vascular, Inc. - Santa Rosa CA

International Classification:

B05D 7/22
B05D 1/18
A61F 2/06
B65B 31/02
A61L 33/00

US Classification:

427 224, 427 225, 4274301, 427238, 623 111, 623 142, 141 7, 141 65

Abstract:

Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

US Patent:

20110067778, Mar 24, 2011

Filed:

Sep 17, 2010

Appl. No.:

12/884362

Inventors:

James E. Mitchell - Windsor CA, US
Dishuan Chu - Rohnert Park CA, US
Justin Peterson - Santa Rosa CA, US
Joseph Traina - Napa CA, US

Assignee:

Medtronic Vascular, Inc. - Santa Rosa CA

International Classification:

B65B 1/04

US Classification:

141 1

Abstract:

Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

US Patent:

20120070563, Mar 22, 2012

Filed:

Sep 17, 2010

Appl. No.:

12/884596

Inventors:

James E. Mitchell - Windsor CA, US
William Heaton - Windsor CA, US
Dishuan Chu - Rohnert Park CA, US
Terry Morgan - Santa Rosa CA, US
Justin Peterson - Santa Rosa CA, US
Joseph Traina - Napa CA, US

Assignee:

Medtronic Vascular, Inc. - Santa Rosa CA

International Classification:

B05D 3/02
B05D 3/10

US Classification:

427 225

Abstract:

Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

US Patent:

20120259314, Oct 11, 2012

Filed:

Apr 11, 2011

Appl. No.:

13/083764

Inventors:

Ya Guo - Santa Rosa CA, US
Stefan Tunev - Santa Rosa CA, US
Joseph Traina - Napa CA, US

Assignee:

Medtronic Vascular, Inc. - Santa Rosa CA

International Classification:

A61M 25/09
A61M 25/10

US Classification:

604509, 604510

Abstract:

A method of recanalizing a chronic total occlusion (CTO) is disclosed. A catheter with a guidewire slidingly received therein is positioned proximally adjacent to the CTO. An occlusion weakening therapy effective to quickly soften and/or loosen the CTO is delivered to the CTO via the catheter. The occlusion weakening therapy includes at least one enzyme and a chelating agent which are selectively deliverable either together or separately depending on the type of material encountered by the guidewire. According to various methods, the enzyme(s) may be delivered if tissue is encountered, the chelating agent may be delivered if calcification is encountered, and both enzyme(s) and chelating agent(s) may be delivered if a fibrous cap is encountered. The distal end of the guidewire may be advanced into the CTO shortly after delivery of the occlusion weakening therapy and is manipulated through the CTO until the guidewire successfully crosses the CTO.

US Patent:

20220296891, Sep 22, 2022

Filed:

Apr 11, 2022

Appl. No.:

17/717958

Inventors:

- Luxembourg, LU
Rudy A. Beasley - Rohnert Park CA, US
Susan Thornton Edwards - Santa Rosa CA, US
Lori Garcia - Santa Rosa CA, US
Michele Lee Silver - Hamden CT, US
Christopher W. Storment - Sonoma CA, US
Carol M. Sullivan - Litchfield Park AZ, US
Joseph A. Traina - Napa CA, US
Stefan Stoyanov Tunev - Santa Rosa CA, US

International Classification:

A61N 1/36
A61N 1/05
A61B 5/20
A61B 5/15
A61B 18/14
A61B 5/145
A61B 5/00

Abstract:

Provided herein are methods, devices, compositions, and kits for monitoring neuromodulation efficacy based on changes in the level or activity of one or more target biomarkers.

US Patent:

20210085831, Mar 25, 2021

Filed:

Nov 30, 2020

Appl. No.:

17/106276

Inventors:

- Mansfield MA, US
Beth Sersen - Santa Rosa CA, US
Daniel Schulz-Jander - Oakland CA, US
Joseph Traina - Napa CA, US
Brian Graham - Santa Rosa CA, US
Carol Sullivan - Litchfield Park AZ, US
Gerald Hodgkinson - Killingworth CT, US

International Classification:

A61L 27/54
A61L 31/16
A61P 31/00
A61B 17/115
A61B 17/32
A61L 27/18
A61L 27/26
A61L 27/28
A61L 27/34
A61L 27/56
A61L 31/04
A61L 31/06
A61L 31/08
A61L 31/10
A61L 31/14

Abstract:

The present disclosure relates to medical devices, and methods for producing and using the devices. In embodiments, the medical device may be a buttress including a porous substrate possessing a therapeutic layer of a chemotherapeutic agent and optional excipient(s) thereon. By varying the form of chemotherapeutic agents and excipients, the medical devices may be used to treat both the area to which the medical device is attached as well as tissue at a distance therefrom.

US Patent:

20200022807, Jan 23, 2020

Filed:

Jul 23, 2019

Appl. No.:

16/519738

Inventors:

- Minneapolis MN, US
Salvador Avelar - Santa Rosa CA, US
Todd Grodrian - Santa Rosa CA, US
Mike Krivoruchko - Forestville CA, US
Mingfei Chen - Santa Rosa CA, US
Christopher Storment - Sonoma CA, US
David A. Shumaker - Eureka MT, US
Mark M. Wegner - Kensington CA, US
Joseph A. Traina - Napa CA, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61F 2/24

Abstract:

A method of forming an electrospun prosthetic valve includes utilizing a rotatable and angularly adjustable prosthetic valve mold. The prosthetic valve mold is set to a first angle. The prosthetic valve mold is rotated at a first rotational velocity and a first layer of electrospun fibers is deposited on the prosthetic valve mold. The prosthetic valve mold is stopped and a frame is positioned over the first layer. The prosthetic valve mold is set to a second angle. The prosthetic valve mold is rotated at a second velocity and a second layer of electrospun fibers is deposited on an outer surface of the first layer and an outer surface of the frame.

US Patent:

20180207321, Jul 26, 2018

Filed:

Dec 11, 2017

Appl. No.:

15/837498

Inventors:

- Mansfield MA, US
Beth Sersen - Santa Rosa CA, US
Daniel Schulz-Jander - Oakland CA, US
Joseph Traina - Napa CA, US
Brian Graham - Santa Rosa CA, US
Carol Sullivan - Santa Rosa CA, US
Gerald Hodgkinson - Guilford CT, US

International Classification:

A61L 27/54
A61P 31/00
A61L 31/14
A61L 31/16
A61L 31/06
A61L 31/08
A61L 27/56
A61L 27/18
A61L 27/28
A61L 27/34
A61L 27/26
A61L 31/10
A61L 31/04
A61B 17/115
A61B 17/32

Abstract:

The present disclosure relates to medical devices, and methods for producing and using the devices. In embodiments, the medical device may be a buttress including a porous substrate possessing a therapeutic layer of a chemotherapeutic agent and optional excipient(s) thereon. By varying the form of chemotherapeutic agents and excipients, the medical devices may be used to treat both the area to which the medical device is attached as well as tissue at a distance therefrom.