Jotham W Coe from 8 Bush Hill Dr, Niantic, CT 06357, age 66

Vice President Of Biopharmworks

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Location:

8 Hl Rd east, Lyme, CT

Industry:

Pharmaceuticals

Work:

Pfizer 1999 - 2012
Research Fellow
Pfizer Global Research and Development 1988 - 2008
Research Fellow

Education:

Massachusetts Institute of Technology 1983 - 1988
PhD, Organic Chemistry Harvard University 1977 - 1981

Skills:

Medicinal Chemistry
Drug Discovery
Chemistry
Organic Synthesis
Drug Development
Neuroscience
Drug Design
Pharmaceutical Industry
Oncology
Synthetic Organic Chemistry
Lc Ms
Chromatography
Pharmacology
Liquid Chromatography Mass Spectrometry
Life Sciences
Lead Change
Neurology
Parallel Synthesis
Pharmaceutical Research
Smoking Cessation
Organic Chemistry

Jotham Coe

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Us Patents

Aryl Fused Azapolycyclic Compounds
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US Patent:

6410550, Jun 25, 2002
Filed:

Sep 28, 1999
Appl. No.:

09/402010
Inventors:

Jotham Wadsworth Coe - Niantic CT
Paige Roanne Palmer Brooks - North Stonington CT
Assignee:

Pfizer INC - New York NY
International Classification:

A61K 3144
US Classification:

514289, 51421021, 5142282, 5142328, 51425302, 51425303, 514256, 514281, 514295, 546 43, 546 74, 546 97, 544 582, 544 60, 544125, 544126, 544242, 544361
Abstract:

Compounds of the formula and their pharmaceutically acceptable salts, wherein R , R , and R are defined as in the specification, intermediates in the synthesis of such compounds. pharmaceutical compositions containing such compounds and methods of using such compounds, in the treatment of neurological and psychological disorders.

Aryl Fused Azapolycyclic Compounds
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US Patent:

6462035, Oct 8, 2002
Filed:

Aug 7, 2000
Appl. No.:

09/582513
Inventors:

Jotham Wadsworth Coe - Niantic CT
Assignee:

Pfizer Inc. - New York NY
International Classification:

A61K 3133
US Classification:

514183, 514290, 540476, 540479, 540482
Abstract:

The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R , R , R and Z are as defined herein, intermediates in the synthesis of such compounds, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of neurological and psychological disorders.

Aryl Fused Azapolycyclic Compounds
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US Patent:

6605610, Aug 12, 2003
Filed:

Feb 25, 2000
Appl. No.:

09/514002
Inventors:

Jotham Wadsworth Coe - Niantic CT
Paige Roanne Palmer Brooks - North Stonington CT
Assignee:

Pfizer Inc - New York NY
International Classification:

A61K 31495
US Classification:

514250, 51421018, 51421021, 5142282, 5142285, 5142328, 514248, 51425302, 51425303, 514256, 514257, 514286, 514289, 514295, 544 582, 544 60, 544125, 544126, 544233, 544242, 544247, 544343, 544361, 546 43, 546 63, 546 74, 546 97
Abstract:

Compounds of the formula and their pharmaceutically acceptable salts, wherein R , R , and R are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.

Aryl Fused Azapolycyclic Compounds
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US Patent:

6706702, Mar 16, 2004
Filed:

Aug 13, 2002
Appl. No.:

10/217771
Inventors:

Jotham Wadsworth Coe - Niantic CT
Assignee:

Pfizer Inc. - New York NY
International Classification:

A61K 3133
US Classification:

514183, 514284, 514287, 514387, 546 43, 546 97, 540476, 540480, 540482, 548149, 548217, 548241
Abstract:

The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R , R , R and Z are as defined herein, intermediates in the synthesis of such compounds, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of neurological and psychological disorders.

Pharmaceutical Composition For The Treatment Of Cns And Other Disorders
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US Patent:

6809094, Oct 26, 2004
Filed:

Aug 28, 2002
Appl. No.:

10/229447
Inventors:

Brian Thomas ONeill - Old Saybrook CT
Jotham Wadsworth Coe - Niantic CT
Christopher J. ODonnell - Mystic CT
Assignee:

Pfizer Inc - New York NY
International Classification:

C07D47108
US Classification:

514221, 540556
Abstract:

The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant 7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant 7 nicotinic receptor agonist.

Pharmaceutical Composition For The Treatment Of Cns And Other Disorders
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US Patent:

6881734, Apr 19, 2005
Filed:

Apr 27, 2004
Appl. No.:

10/833714
Inventors:

Brian Thomas O'Neill - Old Saybrook CT, US
Jotham Wadsworth Coe - Niantic CT, US
Christopher J. O'Donnell - Mystic CT, US
Assignee:

Pfizer Inc. - New York NY
International Classification:

C07D471/08
A61K031/551
A61P025/00
US Classification:

514221, 540556
Abstract:

The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.

Aryl Fused Azapolycyclic Compounds
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US Patent:

6887884, May 3, 2005
Filed:

Feb 13, 2002
Appl. No.:

10/075843
Inventors:

Jotham Wadsworth Coe - Niantic CT, US
Paige Roanne Palmer Brooks - North Stonington CT, US
Assignee:

Pfizer Inc - New York NY
International Classification:

A61K031/44
A61P029/00
C07D221/22
US Classification:

514295, 546 97
Abstract:

Compounds of the formula and their pharmaceutically acceptable salts, wherein R, R, and Rare defined as in the specification, intermediates in the synthesis of such compounds, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of neurological and psychological disorders.

Aryl Fused Azapolycyclic Compounds
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US Patent:

6897310, May 24, 2005
Filed:

Apr 23, 2002
Appl. No.:

10/131278
Inventors:

Jotham Wadsworth Coe - Niantic CT, US
Paige Roanne Palmer Brooks - North Stonington CT, US
Assignee:

Pfizer Inc - New York NY
International Classification:

C07D241/36
C07D221/22
US Classification:

544343, 546 97
Abstract:

Pharmaceutical compositions comprising compounds of the formula and their pharmaceutically acceptable salts, wherein R, R, and Rare defined as in the specification, in combination with another therapeutic agent and methods of using such combinations in the treatment of neurological and psychological disorders.