Juan Juan Wang

US Patent:

20090156620, Jun 18, 2009

Filed:

Nov 5, 2008

Appl. No.:

12/265699

Inventors:

Emma Sharp - Cambridgeshire, GB
Louisa Jane Quegan - Cambridgeshire, GB
Anjali Pandey - Fremont CA, US
Juan Wang - Foster City CA, US
Matthew Nieder - San Francisco CA, US
Wolin Huang - Foster City CA, US

Assignee:

Portola Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07D 409/12
A61K 31/517
C12N 5/06
A61P 9/00
A61P 7/00

US Classification:

51426624, 544285, 435375

Abstract:

The present invention provides novel sulfonylurea salts of a salt of formula (I)

US Patent:

20090163474, Jun 25, 2009

Filed:

Oct 16, 2008

Appl. No.:

12/253010

Inventors:

Songwen Zhang - Lansdale PA, US
Douglas Harnish - Pennsburg PA, US
Mark J. Evans - Radnor PA, US
Juan Wang - Wynnewood PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/55
A61K 31/405

US Classification:

51421301, 514415

Abstract:

Provided are certain methods of treating nonalcoholic fatty liver disease with farnesoid X receptor agonists. Also provided are certain methods of modulating levels of keratinocyte-derived chemokine (KC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), cytokeratin 18 (CK-18), matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-14 (MMP-14), tissue inhibitor of metalloproteinase 1 (TIMP-1), and Cytochrome P450 2E1 (CYP2E1); certain methods of identifying FXR modulators; and certain methods of treating patients with existing cholesterol gallstone disease.

US Patent:

20090185469, Jul 23, 2009

Filed:

Jan 18, 2008

Appl. No.:

12/016311

Inventors:

Juan Wang - San Jose CA, US

International Classification:

G11B 7/28

US Classification:

369 85

Abstract:

A device, system and method is invented to solidify data from temporary storage media to long term storage media without intervention of computer. Those who can not access computer are enabled to use digital recording apparatus, such as digital camera. The operation of the device is restricted in order to increase the ease of use, and to provide the core function. The core function is to read data from temporary storage media, such as various memory cards, and write the data to long term storage media, such as user-writeable CD or DVD. The device features a minimal set of hardware components for accomplishing this function, such as a simplified user interface, an embedded processor, a data reading channel, and a data solidification channel. A data play mode can also be optionally implemented for the user to check the solidified data.

US Patent:

20100151019, Jun 17, 2010

Filed:

Nov 13, 2009

Appl. No.:

12/618511

Inventors:

Chandir Ramani - Brampton, CA
Juan Wang - Foster City CA, US
Anil Kane - Mississauga, CA
Kwok Chow - Mississauga, CA
Joe Lambing - South San Francisco CA, US

Assignee:

Portola Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A61K 9/22
A61K 31/517
A61P 9/00
A61P 7/02

US Classification:

424465, 51426624

Abstract:

A novel solid composition and methods for making and using the solid composition are provided. The solid composition comprises: (a) at least one active agent with a solubility of less than about 0.3 mg/ml in an aqueous solution with a pH of at most about 6.8 at a temperature of about 37 C.; and (b) a hydrophilic polymer matrix composition comprising: i) a hydrophilic polymer selected from the group consisting of METHOCEL™, POLYOX™ WSR 1105 and combinations thereof; and optionally ii) a hydrophobic polymer selected from the group consisting of Ethocel 20 premium; and (c) an alkalizer selected from the group consisting of calcium carbonate, magnesium oxide heavy and sodium bicarbonate; wherein the composition provides at least about 70% release of the active between about 7 to about 12 hours following oral administration.

US Patent:

20110160250, Jun 30, 2011

Filed:

Dec 16, 2010

Appl. No.:

12/970818

Inventors:

Anjali Pandey - Fremont CA, US
Juan Wang - Foster City CA, US
Joseph Lambing - Burlingame CA, US

International Classification:

A61K 31/4439
C07D 409/14
C12N 9/99
A61P 9/10
A61P 7/02

US Classification:

514341, 5462751, 435184

Abstract:

The present invention provides crystalline forms of a mesylate salt of the compound 5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide and pharmaceutical compositions and methods thereof.

US Patent:

20120129876, May 24, 2012

Filed:

Jun 22, 2011

Appl. No.:

13/166763

Inventors:

Emma Sharp - Cambridgeshire, GB
Louisa Jane Quegan - Cambridgeshire, GB
Anjali Pandey - Fremont CA, US
Juan Wang - Foster City CA, US
Matthew Nieder - San Francisco CA, US
Wolin Huang - Foster City CA, US

Assignee:

Portola Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A61K 31/517
A61P 9/10
A61P 7/02
C07D 409/12
A01N 1/02

US Classification:

51426624, 544285, 435 2

Abstract:

The present invention provides novel sulfonylurea salts of a salt of formula (I)

US Patent:

20130165459, Jun 27, 2013

Filed:

Jan 12, 2011

Appl. No.:

13/521906

Inventors:

Juan Wang - Foster City CA, US
Chandir Ramani - Brampton, CA
Joe Lambing - South San Francisco CA, US
Christine Ye - South San Francisco CA, US
Elizabeth Vadas - Dorval, CA
Julian Taillemite - Huningue, FR
Marie-Pierre Filliot - Geispitzen, FR
Dieter Becker - Freiburg, DE

Assignee:

NORVARTIS PHARMA AG - Basel
PORTOLA PHARMACEUTICALS, INC. - San Francisco CA

International Classification:

A61K 45/06
A61K 31/64

US Classification:

51426624

Abstract:

The present invention is concerned with a solid delivery form of elinogrel for the treatment of thrombosis which is notable for its multi-pH dissolution, immediate release and improved pharmacokinetic properties and stability in storage. The delivery and dosage form is a solid, oral formulation comprising: a) at least about 15% by weight elinogrel or a pharmaceutically acceptable salt thereof relative to the total weight of the overall pharmaceutical composition, and b) at least one pharmaceutically acceptable carrier. A further aspect of the present invention concerns the preparation and use of such a formulation.

US Patent:

20130172374, Jul 4, 2013

Filed:

Oct 1, 2012

Appl. No.:

13/633055

Inventors:

Juan Wang - Foster City CA, US
Anil Kane - Mississauga, CA
Kwok Chow - Mississauga, CA
Joe Lambing - South San Francisco CA, US

Assignee:

Portola Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

A61K 47/38
A61K 47/10
A61K 9/00

US Classification:

51426624, 514781, 5147723, 514770, 514769, 514784, 264109

Abstract:

A novel solid composition and methods for making and using the solid composition are provided. The solid composition comprises: (a) at least one active agent with a solubility of less than about 0.3 mg/ml in an aqueous solution with a pH of at most about 6.8 at a temperature of about 37 C.; and (b) a hydrophilic polymer matrix composition comprising: i) a hydrophilic polymer selected from the group consisting of METHOCEL™, POLYOX™ WSR 1105 and combinations thereof; and optionally ii) a hydrophobic polymer selected from the group consisting of Ethocel 20 premium; and (c) an alkalizer selected from the group consisting of calcium carbonate, magnesium oxide heavy and sodium bicarbonate; wherein the composition provides at least about 70% release of the active between about 7 to about 12 hours following oral administration.