Juliane M Bauer

US Patent:

20040105883, Jun 3, 2004

Filed:

Jul 31, 2003

Appl. No.:

10/633390

Inventors:

Ping Gao - Portage MI, US
Juliane Bauer - Portage MI, US
Xiaorong He - Kalamazoo MI, US

International Classification:

A61K009/48
A61K009/64

US Classification:

424/452000, 424/456000

Abstract:

The present invention provides a pharmaceutical dosage form comprising a fill material sealed in a gelatin capsule; the fill material comprises (a) a selective COX-2 inhibitory drug of low water solubility, and (b) a primary or secondary amine compound in an amount sufficient to inhibit cross-linking of gelatin in said gelatin capsule upon storage of the dosage form in a closed container maintained at 40 C. and 75% relative humidity for a period of 6 months.

US Patent:

20040105884, Jun 3, 2004

Filed:

Jul 31, 2003

Appl. No.:

10/632737

Inventors:

Ping Gao - Portage MI, US
Juliane Bauer - Portage MI, US
Gary Ewing - Kalamazoo MI, US
David Sperry - Kalamazoo MI, US

International Classification:

A61K031/415
A61K009/64
A61K031/355
A61K033/04

US Classification:

424/456000, 424/703000, 514/406000, 514/473000, 514/458000, 514/474000

Abstract:

The present invention provides a pharmaceutical dosage form comprising a fill material sealed in a gelatin capsule; the fill material comprises (a) a selective COX-2 inhibitory drug of low water solubility, and (b) a sulfite compound in an amount sufficient to inhibit cross-linking of gelatin in said gelatin capsule upon storage of the dosage form in a closed container maintained at 40 C. and 75% relative humidity for a period of 6 months.

US Patent:

20050112197, May 26, 2005

Filed:

Oct 20, 2004

Appl. No.:

10/969140

Inventors:

Ping Gao - Portage MI, US
Tiehua Huang - Kalamazoo MI, US
Russell Robins - Portage MI, US
Juliane Bauer - Portage MI, US
Jane Guido - Vicksburg MI, US
Andrew Brugger - Libertyville IL, US
Aziz Karim - Skokie IL, US
Fred Hassan - Peapack NJ, US
James Forbes - Glenview IL, US

International Classification:

A61K031/44
A61K031/42
A61K031/415
A61K031/365
A61K031/18
A61K009/20

US Classification:

424464000, 514357000, 514378000, 514406000, 514471000, 514602000

Abstract:

An orally deliverable pharmaceutical composition is provided comprising an aminosulfonyl-comprising drug, for example a selective cyclooxygenase-2 inhibitory drug such as celecoxib, and a solvent liquid comprising a polyethylene glycol and one or more free radical-scavenging antioxidants. At least a substantial part of the drug is in dissolved form in the solvent liquid. The composition has rapid-onset properties and is useful in treatment of cyclooxygenase-2 mediated conditions and disorders.

US Patent:

20030105144, Jun 5, 2003

Filed:

Apr 9, 2002

Appl. No.:

10/119118

Inventors:

Ping Gao - Portage MI, US
Tiehua Huang - Kalamazoo MI, US
Russell Robins - Portage MI, US
Juliane Bauer - Portage MI, US
Jane Guido - Vicksburg MI, US
Andrew Brugger - Libertyville IL, US
Aziz Karim - Skokie IL, US
Fred Hassan - Peapack NJ, US
James Forbes - Glenview IL, US

International Classification:

A61K031/44
A61K031/42
A61K031/415
A61K031/18
A61K031/365

US Classification:

514/357000, 514/406000, 514/378000, 514/471000, 514/602000

Abstract:

An orally deliverable pharmaceutical composition is provided comprising an aminosulfonyl-comprising drug, for example a selective cyclooxygenase-2 inhibitory drug such as celecoxib, and a solvent liquid comprising a polyethylene glycol and one or more free radical-scavenging antioxidants. At least a substantial part of the drug is in dissolved form in the solvent liquid. The composition has rapid-onset properties and is useful in treatment of cyclooxygenase-2 mediated conditions and disorders.