Julie V Heath

US Patent:

20190290648, Sep 26, 2019

Filed:

Nov 3, 2017

Appl. No.:

16/347942

Inventors:

- Thousand Oaks CA, US
Paul John DRANSFIELD - Arlington MA, US
James S. HARVEY - Arlington MA, US
Julie Anne HEATH - Chico CA, US
Jonathan HOUZE - Cambridge MA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David J. KOPECKY - Washington D.C. DC, US
Su-Jen LAI - Cambridge MA, US
Zhihua MA - Lexington MA, US
Nobuko NISHIMURA - West Hills CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Wen-Chen YEH - Belmont CA, US
Philip Dean RAMSDEN - Acton MA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 31/506
A61P 9/04
C07D 403/12
C07D 405/14
C07D 401/14

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I) (II) where the definitions of the variables are provided herein.

US Patent:

20190284173, Sep 19, 2019

Filed:

Nov 3, 2017

Appl. No.:

16/347955

Inventors:

- Thousand Oaks CA, US
Yinhong CHEN - Hayward CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Paul John DRANSFIELD - Arlington MA, US
James S. HARVEY - Arlington MA, US
Julie Anne HEATH - Chico CA, US
Jonathan HOUZE - Cambridge MA, US
Aarif Yusuf KHAKOO - Woodside CA, US
Su-Jen LAI - Cambridge MA, US
Zhihua MA - Lexington MA, US
Nobuko NISHIMURA - West Hills CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Wen-Chen YEH - Belmont CA, US
Charles KREIMAN - Hopkinton MA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 403/14
C07D 403/04
C07D 249/14
C07D 403/12
C07D 401/04
C07D 401/14
C07D 405/14
C07D 239/24
C07D 417/12
C07D 241/12
A61P 9/04

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.

US Patent:

20190275008, Sep 12, 2019

Filed:

Nov 3, 2017

Appl. No.:

16/347903

Inventors:

- Thousand Oaks CA, US
Ning CHEN - Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
James S. HARVEY - Arlington MA, US
Julie Anne HEATH - Chico CA, US
Lars V. HEUMANN - Redwood City CA, US
Jonathan HOUZE - Cambridge MA, US
Frank KAYSER - San Francisco CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David j. KOPECKY - Washington D.C. DC, US
Su-Jen LAI - Cambridge MA, US
Zhihua MA - Lexington MA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Malgorzata WANSKA - Camarillo CA, US
Wen-Chen YEH - Belmont CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 31/4196
C07D 405/14
C07D 405/04
A61K 31/506
C07D 405/12
C07D 471/04
A61K 31/437
C07F 7/08
A61K 31/4439
A61K 31/501
C07D 413/12
A61K 31/421
C07D 239/26
C07D 403/12

Abstract:

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.

US Patent:

20190100510, Apr 4, 2019

Filed:

Dec 3, 2018

Appl. No.:

16/207360

Inventors:

- Thousand Oaks CA, US
Zice Fu - Foster City CA, US
Julie Anne Heath - Chico CA, US
Jeffrey T. Mihalic - San Francisco CA, US
Vatee Pattaropong - Bedford MA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 401/12
A61K 31/437
C07D 417/14
A61K 45/06
C07B 57/00
C07B 59/00
C07D 211/54
C07D 213/71
C07D 213/82
C07D 239/26
C07D 239/30
C07D 241/12
C07D 241/24
C07D 249/08
C07D 471/04
C07D 413/14
C07D 413/04
C07D 401/04
C07D 213/61
C07D 239/34
C07D 241/18
C07F 7/08
C07D 295/16
C07C 311/13
A61K 31/695
A61K 31/4439
A61K 31/444
A61K 31/497
A61K 31/501
A61K 31/506
A61K 31/513
C07D 405/14

Abstract:

Bromotriazole intermediates are useful in the synthesis of agonists of the APH receptor. Such compounds include those selected from

US Patent:

20190062276, Feb 28, 2019

Filed:

Mar 21, 2018

Appl. No.:

15/927426

Inventors:

- Thousand Oaks CA, US
Ana Gonzalez Buenrostro - San Mateo CA, US
Hilary Plake Beck - Emerald Hills CA, US
Xiaoqi Chen - Palo Alto CA, US
Richard Victor Connors - Scottsdale AZ, US
Jeffrey Deignan - San Francisco CA, US
Jason A. Duquette - Millbrae CA, US
John Eksterowicz - San Francisco CA, US
Benjamin Fisher - San Mateo CA, US
Brian M. Fox - Brisbane CA, US
Jiasheng Fu - Foster City CA, US
Zice Fu - Foster City CA, US
Felix Gonzalez Lopez De Turiso - Cambridge MA, US
Darin J. Gustin - Half Moon Bay CA, US
Julie A. Heath - Chico CA, US
Xin Huang - Wellesley MA, US
XianYun Jiao - Belmont CA, US
Michael G. Johnson - San Francisco CA, US
Frank Kayser - San Francisco CA, US
David John Kopecky - Studio City CA, US
SuJen Lai - Boston MA, US
Yihong Li - Johns Creek GA, US
Zhihong Li - Millbrae CA, US
Jiwen Liu - Foster City CA, US
Jonathan D. Low - Reseda CA, US
Brian S. Lucas - Arlington MA, US
Zhihua Ma - Lexington MA, US
Lawrence R. McGee - Pacifica CA, US
Joel McIntosh - Pacifica CA, US
Dustin L. McMinn - Pacifica CA, US
Julio C. Medina - San Carlos CA, US
Jeffrey Thomas Mihalic - San Francisco CA, US
Steven H. Olson - Millbrae CA, US
Yosup Rew - Foster City CA, US
Philip M. Roveto - Albuquerque NM, US
Daqing Sun - Foster City CA, US
Xiaodong Wang - Johns Creek GA, US
Yingcai Wang - Millbrae CA, US
Xuelei Yan - Foster City CA, US
Ming Yu - Foster City CA, US
Jiang Zhu - Palo Alto CA, US

International Classification:

C07D 211/76
C07D 279/02
C07D 405/12
C07D 405/04
C07D 491/153
C07D 407/04
C07D 401/12
C07D 401/06
C07D 417/06
C07D 413/06
C07D 491/08
C07D 401/04
C07D 471/10
C07D 221/20
C07D 417/14
C07D 498/08
C07D 409/04
C07D 407/06
C07D 417/12
C07D 498/14
C07D 409/12
C07D 498/20

Abstract:

The present invention provides MDM2 inhibitor compounds of Formula I,

US Patent:

20180319773, Nov 8, 2018

Filed:

Jul 12, 2018

Appl. No.:

16/033632

Inventors:

- Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
Julie Anne HEATH - Chico CA, US
Daniel B. HORNE - Natick MA, US
Jonathan HOUZE - Cambridge MA, US
Matthew R. KALLER - Ventura CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Washington DC, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Kevin YANG - San Gabriel CA, US
Wen-Chen YEH - Belmont CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Robert P. FARRELL - Thousand Oaks CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Ted C. JUDD - Granada Hills CA, US
Frank KAYSER - San Francisco CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 401/12
A61K 31/437
C07D 417/14
A61K 45/06
C07B 57/00
C07B 59/00
C07D 211/54
C07D 213/71
C07D 213/82
C07D 239/26
C07D 239/30
C07D 241/12
C07D 241/24
C07D 249/08
C07D 471/04
C07D 413/14
C07D 413/04
C07D 401/04
C07D 213/61
C07D 239/34
C07D 241/18
C07F 7/08
C07D 295/16
C07C 311/13
A61K 31/695
A61K 31/4439
A61K 31/444
A61K 31/497
A61K 31/501
A61K 31/506
A61K 31/513
C07D 405/14

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20180222895, Aug 9, 2018

Filed:

Apr 5, 2018

Appl. No.:

15/945852

Inventors:

- Thousand Oaks CA, US
Alan C. Cheng - San Francisco CA, US
Richard V. Connors - Mesa AZ, US
Mikkel V. Debenedetto - Waltham MA, US
Paul John Dransfield - Arlington MA, US
Zice Fu - Foster City CA, US
James S. Harvey - Brookline MA, US
Julie Anne Heath - Chico CA, US
Jonathan Houze - Cambridge MA, US
Ted C. Judd - Granada Hills CA, US
David John Kopecky - Washington DC, US
Su-Jen Lai - Boston MA, US
Zhihua Ma - Lexington MA, US
Nobuko Nishimura - West Hills CA, US
Steven H. Olson - Millbrae CA, US
Vatee Pattaropong - Bedford MA, US
Xiaodong Wang - Johns Creek GA, US

International Classification:

C07D 405/14
C07D 409/14
C07D 403/14
C07D 403/04
C07D 401/14
A61K 45/06
A61K 31/4439
A61K 31/437
A61K 31/506
A61K 31/5383
C07D 498/04
C07D 405/04
C07D 471/04
A61K 31/497

Abstract:

Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor:where the definitions of the variables are provided herein.

US Patent:

20170320860, Nov 9, 2017

Filed:

May 2, 2017

Appl. No.:

15/584109

Inventors:

- Thousand Oaks CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Paul John DRANSFIELD - Arlington MA, US
Zice FU - Foster City CA, US
James S. HARVEY - Brookline MA, US
Julie Anne HEATH - Chico CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Jonathan HOUZE - Cambridge MA, US
Ted C. JUDD - Granada Hills CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Studio City CA, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Wen-Chen YEH - Belmont CA, US

International Classification:

C07D 405/14
C07D 471/04
C07D 405/04
A61K 31/5383
A61K 31/437
A61K 31/506
A61K 31/497
A61K 31/4439
C07D 498/04
A61K 45/06

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.