Julie E Newman

US Patent:

6750214, Jun 15, 2004

Filed:

Jun 4, 2003

Appl. No.:

10/455546

Inventors:

Alan John Collis - New York NY 10017
David Nathan Abraham Fox - New York NY 10017
Julie Newman - New York NY 10017

International Classification:

A01N 31519

US Classification:

51421706, 514257, 5142285, 5142328, 51425216, 5142594, 514218, 544 582, 544115, 544247, 540575, 540600

Abstract:

The invention provides compounds of formula (I), wherein R represents C alkoxy optionally substituted by one or more fluorine atoms; R represents H or C alkoxy optionally substituted by one or more fluorine atoms; R represents one or more groups independently selected from H, halogen, C alkoxy and CF ; in addition, R and one R group may together represent âOCH â, the methylene group being attached to the ortho-position of the pendant phenyl ring; R represents a 4-, 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent or represents a cyclic group or an open chain group; and the pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of inter alia benign prostatic hyperplasia.