Jun Zhang

US Patent:

6824767, Nov 30, 2004

Filed:

Feb 8, 1999

Appl. No.:

09/246129

Inventors:

Guo-Liang Yu - Berkeley CA
Jian Ni - Rockville MD
Craig A. Rosen - Laytonsville MD
Jun Zhang - Bethesda MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3819

US Classification:

424 851, 530324, 530350, 5303873, 530866, 514 12

Abstract:

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

US Patent:

7597886, Oct 6, 2009

Filed:

Jul 6, 2001

Appl. No.:

09/899059

Inventors:

Guo-Liang Yu - Berkeley CA, US
Jian Ni - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Jun Zhang - Bethesda MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 39/395
C07K 14/525

US Classification:

4241301, 4241331, 4241411, 4241421, 5303871, 5303873, 5303881, 53038815, 53038823, 930144

Abstract:

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

US Patent:

7820798, Oct 26, 2010

Filed:

Aug 10, 2007

Appl. No.:

11/837082

Inventors:

Guo-Liang Yu - Berkeley CA, US
Jian Ni - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Jun Zhang - San Diego CA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 16/28
C07K 16/18
C07K 16/22
C07K 16/46
C12N 5/00
G01N 33/53

US Classification:

5303882, 5303871, 5303873, 5303881, 5303891, 435 71, 435326

Abstract:

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

US Patent:

8093363, Jan 10, 2012

Filed:

Sep 10, 2010

Appl. No.:

12/879210

Inventors:

Guo-Liang Yu - Berkeley CA, US
Jian Ni - Germantown MD, US
Craig A. Rosen - Laytonsville MD, US
Jun Zhang - San Diego CA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 16/28
C07K 16/18
C07K 16/22
C07K 16/46
C07K 14/525
C12N 5/00
G01N 33/53

US Classification:

53038823, 5303871, 5303881, 5303892, 435 71, 435326, 930144

Abstract:

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

US Patent:

8188235, May 29, 2012

Filed:

Jun 9, 2009

Appl. No.:

12/480991

Inventors:

Arvind Rajpal - San Francisco CA, US
Madhav Devalaraja - Gaithersburg MD, US
Kristopher Toy - San Jose CA, US
Lan Yang - Morgan Hill CA, US
Haichun Huang - Fremont CA, US
Jun Zhang - Tracy CA, US
Peter Brams - Sacramento CA, US
Brigitte Devaux - Palo Alto CA, US
David B. Passmore - San Carlos CA, US

Assignee:

Pfizer Inc. - New York NY
Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 16/00
C07K 16/24
C07K 16/46

US Classification:

5303871, 5303879, 53038823, 5303873

Abstract:

Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.

US Patent:

8436158, May 7, 2013

Filed:

Apr 24, 2012

Appl. No.:

13/454296

Inventors:

Arvind Rajpal - San Francisco CA, US
Madhav Narasimha Devalaraja - Gaithersburg MD, US
Kristopher Toy - San Jose CA, US
Lan Yang - Morgan Hill CA, US
Haichun Huang - Fremont CA, US
Jun Zhang - Tracy CA, US
Peter Brams - Sacramento CA, US
Brigitte Devaux - Palo Alto CA, US
David B. Passmore - San Carlos CA, US

Assignee:

Pfizer Inc. - New York NY
Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/02
C12N 5/07
C12N 5/16

US Classification:

536 231, 435326

Abstract:

Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.

US Patent:

20030027284, Feb 6, 2003

Filed:

Aug 7, 1998

Appl. No.:

09/131237

Inventors:

GUO-LIANG YU - SAN MATEO CA, US
JIAN NI - ROCKVILLE MD, US
CRAIG A. ROSEN - LAYTONSVILLE MD, US
JUN ZHANG - BETHESDA MD, US

International Classification:

A61K038/00
C07H021/04
C12P021/06
C12P021/02
A61K039/395
A61K039/40
A61K039/42
C12N015/00
C12N015/09
C12N015/63
C12N015/70
C12N015/74
C12N005/00
C12N005/02

US Classification:

435/069500, 435/320100, 435/325000, 514/012000, 536/023500, 424/136100

Abstract:

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory acitvities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

US Patent:

20030129189, Jul 10, 2003

Filed:

Aug 23, 2002

Appl. No.:

10/226294

Inventors:

Guo-Liang Yu - Berkeley CA, US
Jian Ni - Germantown MD, US
Craig Rosen - Laytonsville MD, US
Jun Zhang - San Diego CA, US

International Classification:

A61K039/395

US Classification:

424/145100

Abstract:

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.